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    b2m beta-2-microglobulin [ Danio rerio (zebrafish) ]

    Gene ID: 30400, updated on 9-Dec-2024

    Summary

    Official Symbol
    b2mprovided by ZNC
    Official Full Name
    beta-2-microglobulinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-88
    See related
    Ensembl:ENSDARG00000053136 AllianceGenome:ZFIN:ZDB-GENE-980526-88
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bwm; wu:fa94c05; wu:fb10a09
    Summary
    Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation of peptide antigen via MHC class I and immune response. Predicted to be located in extracellular region. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See b2m in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12793396..12795493, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12794547..12796644, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene helicase (DNA) B Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene high mobility group AT-hook 2 Neighboring gene uncharacterized LOC103910419

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159768.1NP_001153240.1  beta-2-microglobulin precursor

      See identical proteins and their annotated locations for NP_001153240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC162435, CR558305
      UniProtKB/Swiss-Prot
      Q04475
      UniProtKB/TrEMBL
      B0UYS1
      Related
      ENSDARP00000110049.2, ENSDART00000131026.3
      Conserved Domains (1) summary
      cd05770
      Location:23113
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin
    2. NM_131163.2NP_571238.1  beta-2-microglobulin precursor

      See identical proteins and their annotated locations for NP_571238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI544722, BC062841, CR558305
      UniProtKB/Swiss-Prot
      Q04475
      UniProtKB/TrEMBL
      B0UYS1
      Related
      ENSDARP00000069612.4, ENSDART00000075127.6
      Conserved Domains (1) summary
      cd05770
      Location:23113
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      12793396..12795493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)