kdm7aa lysine (K)-specific demethylase 7Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kdm7aaprovided by ZNC
Official Full Name: lysine (K)-specific demethylase 7Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9829
See related: Ensembl:ENSDARG00000018111 AllianceGenome:ZFIN:ZDB-GENE-030131-9829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb414; kdm7a; jhdm1da; sb:cb414; zgc:123306; DKEY-105O6.2; si:dkey-105o6.2
Summary: Enables histone H3K27me2/H3K27me3 demethylase activity and histone H3K9 demethylase activity. Involved in midbrain development. Acts upstream of or within chromatin remodeling. Predicted to be located in nucleus. Is expressed in several structures, including anterior axial hypoblast; immature eye; margin; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human KDM7A (lysine demethylase 7A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (22482661..22519525, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (22763855..22798550, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a JmjC domain-containing protein that catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27
Title: KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables 2-oxoglutarate-dependent dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27me2/H3K27me3 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27me2/H3K27me3 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K9 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K20 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysine-specific demethylase 7A

Names: jmjC domain-containing histone demethylation protein 1D-A; jumonji C domain containing histone demethylase 1 homolog D; jumonji C domain containing histone demethylase 1 homolog Da

NP_001333080.1

EC 1.14.11.-

XP_068075614.1

EC 1.14.11.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.