atp1a1a.5 ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp1a1a.5provided by ZNC
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-020501-1
See related: Ensembl:ENSDARG00000040252 AllianceGenome:ZFIN:ZDB-GENE-020501-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb709
Summary: Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including immature eye; mucus secreting cell; nervous system; otic vesicle; and renal system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (1838164..1850104)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (1690370..1702310)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP1a1a.1, ATP1a1a.2, and ATP1a1a.5 may provide driving force for Na+-coupled cotransporter activity in gill ionocytes.
Title: Expression regulation of Na+-K+-ATPase alpha1-subunit subtypes in zebrafish gill ionocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5

Names: ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 5; ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178099.2 → NP_835200.1 ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5

See identical proteins and their annotated locations for NP_835200.1

Status: PROVISIONAL

Source sequence(s)

AY094620

UniProtKB/TrEMBL

Q8JIV1

Related

ENSDARP00000013042.8, ENSDART00000006013.9

Conserved Domains (6) summary

smart00831
Location:41 → 115

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:603 → 752

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:32 → 1023

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:134 → 365

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:799 → 1008

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:427 → 521

Cation_ATPase; Cation transport ATPase (P-type)