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    sparc secreted protein, acidic, cysteine-rich (osteonectin) [ Danio rerio (zebrafish) ]

    Gene ID: 321357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sparcprovided by ZNC
    Official Full Name
    secreted protein, acidic, cysteine-rich (osteonectin)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9
    See related
    Ensembl:ENSDARG00000019353 AllianceGenome:ZFIN:ZDB-GENE-030131-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hm:zeh0062
    Summary
    Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to be located in basement membrane; extracellular region; and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sparc in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (25938895..25956824, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (25641650..25659618, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene glycine receptor, alpha 1 Neighboring gene GTPase activating protein (SH3 domain) binding protein 1 Neighboring gene solute carrier family 36 member 1 Neighboring gene antioxidant 1 copper chaperone Neighboring gene melatonin receptor type 1A like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular response to ultraviolet radiation exposure in fish embryos: implications for survival and morphological development. Torres Nuñez E, et al. Photochem Photobiol, 2012 May-Jun. PMID 22242699
    2. Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region. Torres-Núñez E, et al. Dev Dyn, 2015 May. PMID 25728805
    3. Sparc protein is required for normal growth of zebrafish otoliths. Kang YJ, et al. J Assoc Res Otolaryngol, 2008 Dec. PMID 18784957, Free PMC Article
    4. Overexpression of p204 leads to abnormal embryos and osteogenesis in zebrafish. Zhao HB, et al. Front Biosci (Elite Ed), 2011 Jan 1. PMID 21196291
    5. Molecular cloning and characterization of the matricellular protein Sparc/osteonectin in flatfish, Scophthalmus maximus, and its developmental stage-dependent transcriptional regulation during metamorphosis. Torres-Núñez E, et al. Gene, 2015 Sep 1. PMID 25981593

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data identify a contributory role for DNA methylation in regulating sparc expression in zebrafish embryogenesis.
      Title: Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region.
    2. Results establish a role for an ECM protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
      Title: Critical role of the matricellular protein SPARC in mediating erythroid progenitor cell development in zebrafish.
    3. Sparc is directly required for normal otolith growth
      Title: Sparc protein is required for normal growth of zebrafish otoliths.
    4. Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
      Title: Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semicircular canal morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within semicircular canal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SPARC
    Names
    osn
    osteonectin
    secreted acidic cysteine rich glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001942.1 → NP_001001942.1  SPARC precursor

      See identical proteins and their annotated locations for NP_001001942.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071436
      UniProtKB/TrEMBL
      Q6IQH0
      Related
      ENSDARP00000039659.4, ENSDART00000039660.6
      Conserved Domains (3) summary
      cd00252
      Location:142 → 289
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      cd01328
      Location:59 → 140
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      pfam10591
      Location:142 → 275
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      25938895..25956824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213159.1 → XP_068069260.1  SPARC isoform X1

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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