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    pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 [ Danio rerio (zebrafish) ]

    Gene ID: 548346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pik3c3provided by ZNC
    Official Full Name
    phosphatidylinositol 3-kinase, catalytic subunit type 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050410-13
    See related
    Ensembl:ENSDARG00000054829 AllianceGenome:ZFIN:ZDB-GENE-050410-13
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7147158; wu:fc13g06; wu:fz51e12; zgc:112016; zgc:113009
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity. Predicted to be involved in several processes, including autophagosome assembly; phosphatidylinositol-3-phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Used to study inflammatory bowel disease. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3c3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24593209..24621696, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24322098..24350539, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-75h12.7 Neighboring gene uncharacterized LOC137490272 Neighboring gene microseminoprotein, prostate associated 1 Neighboring gene GP1 homolog, RAB6A GEF complex partner 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fibroblast Growth Factor 21 Augments Autophagy and Reduces Apoptosis in Damaged Liver to Improve Tissue Regeneration in Zebrafish. Qiang W, et al. Front Cell Dev Biol, 2021. PMID 34746149, Free PMC Article
    2. Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Zhao S, et al. Nat Commun, 2018 Jul 6. PMID 29980668, Free PMC Article
    3. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
    4. Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Zhou Z, et al. Front Physiol, 2020. PMID 33329019, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results not only reveal a role of PIK3C3 in gut homeostasis, but also provide a zebrafish inflammatory bowel disease model.
      Title: Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC191642

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase catalytic subunit type 3
    Names
    phosphoinositide-3-kinase, class 3
    NP_001315462.1
    XP_021333200.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328533.1 → NP_001315462.1  phosphatidylinositol 3-kinase catalytic subunit type 3

      Status: VALIDATED

      Source sequence(s)
      BX510349, EH542626, EH563762
      UniProtKB/TrEMBL
      A0A8M1P518, F1Q9F3
      Related
      ENSDARP00000092039.3, ENSDART00000101265.5
      Conserved Domains (3) summary
      cd08397
      Location:25 → 185
      C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
      cd00870
      Location:282 → 494
      PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
      cd00896
      Location:530 → 874
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

    RNA

    1. NR_137316.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX510349
      Related
      ENSDART00000127155.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      24593209..24621696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477525.2 → XP_021333200.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QGZ6
      Conserved Domains (3) summary
      cd08397
      Location:25 → 194
      C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
      cd00870
      Location:291 → 503
      PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
      cd00896
      Location:539 → 883
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017550.2: Suppressed sequence

      Description
      NM_001017550.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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