pik3ip1 phosphoinositide-3-kinase interacting protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3ip1provided by ZNC
Official Full Name: phosphoinositide-3-kinase interacting protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031030-14
See related: Ensembl:ENSDARG00000003281 AllianceGenome:ZFIN:ZDB-GENE-031030-14
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66482
Summary: Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including immature eye; nervous system; optic primordium; pancreatic system; and yolk syncytial layer. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (20866572..20879565, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (20362772..20375704, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide-3-kinase-interacting protein 1

Names: HGFL; kringle domain-containing protein HGFL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198374.2 → NP_938188.2 phosphoinositide-3-kinase-interacting protein 1 precursor

Status: VALIDATED

Source sequence(s)

BX927203

UniProtKB/Swiss-Prot

Q7SXB3

Related

ENSDARP00000115818.1, ENSDART00000134697.2