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    tnfaip6 tumor necrosis factor, alpha-induced protein 6 [ Danio rerio (zebrafish) ]

    Gene ID: 678516, updated on 4-Jan-2025

    Summary

    Official Symbol
    tnfaip6provided by ZNC
    Official Full Name
    tumor necrosis factor, alpha-induced protein 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-2654
    See related
    Ensembl:ENSDARG00000093440 AllianceGenome:ZFIN:ZDB-GENE-060421-2654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136830; si:dkey-89p3.1
    Summary
    Predicted to enable hyaluronic acid binding activity. Predicted to be involved in negative regulation of inflammatory response. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See tnfaip6 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22764235..22779813)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22953366..22968944)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 44 Neighboring gene integrin, beta 5 Neighboring gene replication timing regulatory factor 1 Neighboring gene nebulin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC136830

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor-inducible gene 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040243.1NP_001035333.2  tumor necrosis factor-inducible gene 6 protein precursor

      See identical proteins and their annotated locations for NP_001035333.2

      Status: PROVISIONAL

      Source sequence(s)
      BC115283
      UniProtKB/TrEMBL
      A0A8M1N8R8, B0UY56, Q1RLU5
      Related
      ENSDARP00000085308.4, ENSDART00000090875.5
      Conserved Domains (2) summary
      cd03515
      Location:46138
      Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...
      pfam00431
      Location:145254
      CUB; CUB domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      22764235..22779813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395279.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      296616..312564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)