sgms1a sphingomyelin synthase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sgms1aprovided by ZNC
Official Full Name: sphingomyelin synthase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-201
See related: Ensembl:ENSDARG00000057053 AllianceGenome:ZFIN:ZDB-GENE-041114-201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91976; wu:fi06d09
Summary: Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to act upstream of or within apoptotic process and sphingolipid metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (23729717..23765068)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (23733951..23745044)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi06d09.x1 (e-PCR)
- UniSTS:196701

fi57f08.x1 (e-PCR)
- UniSTS:197728

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ceramide cholinephosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotransferase activity, for other substituted phosphate groups	IEA Inferred from Electronic Annotation more info
enables sphingomyelin synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingomyelin synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingomyelin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein LOC492359

NP_001007326.1

EC 2.7.8.27

XP_068070494.1

EC 2.7.8.27

XP_068070495.1

EC 2.7.8.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007325.2 → NP_001007326.1 uncharacterized protein LOC492359

See identical proteins and their annotated locations for NP_001007326.1

Status: VALIDATED

Source sequence(s)

CR384057

UniProtKB/TrEMBL

A0A8M1N376, Q5U3Z9

Related

ENSDARP00000144395.1, ENSDART00000179026.2

Conserved Domains (3) summary

cd09514
Location:1 → 72

SAM_SGMS1; SAM domain of sphingomyelin synthase

smart00454
Location:4 → 43

SAM; Sterile alpha motif

pfam14360
Location:282 → 355

PAP2_C; PAP2 superfamily C-terminal