ppp2r2d protein phosphatase 2, regulatory subunit B, delta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp2r2dprovided by ZNC
Official Full Name: protein phosphatase 2, regulatory subunit B, deltaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2086
See related: Ensembl:ENSDARG00000102009 AllianceGenome:ZFIN:ZDB-GENE-040426-2086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76887; PP2A-Bdelta; si:ch211-136d9.1
Summary: Predicted to enable protein phosphatase regulator activity. Acts upstream of or within with a positive effect on myoblast fusion. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Orthologous to human PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (41718539..41759717, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (40559151..41217522, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212880.2 → NP_998045.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

See identical proteins and their annotated locations for NP_998045.1

Status: VALIDATED

Source sequence(s)

CABZ01046681, CT737148, CU607080

UniProtKB/Swiss-Prot

Q6NY64

Related

ENSDARP00000131296.2, ENSDART00000165152.2

Conserved Domains (3) summary

COG5170
Location:7 → 442

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:31 → 79

7WD40; WD40 repeat [structural motif]

cl02567
Location:29 → 370

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...