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    tyw3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 436884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyw3provided by ZNC
    Official Full Name
    tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-355
    See related
    Ensembl:ENSDARG00000038222 AllianceGenome:ZFIN:ZDB-GENE-040718-355
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92277
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tyw3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (11119365..11126221)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11335788..11342622)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 151 member A Neighboring gene leucine rich repeat containing 53 Neighboring gene crystallin, zeta (quinone reductase) Neighboring gene solute carrier family 44 member 5a Neighboring gene LIM homeobox 8a Neighboring gene uncharacterized LOC108179505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA wybutosine-synthesizing protein 3 homolog
    Names
    tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
    tRNA-yW-synthesizing protein 3
    NP_001002611.1
    XP_005171216.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002611.1 → NP_001002611.1  tRNA wybutosine-synthesizing protein 3 homolog

      See identical proteins and their annotated locations for NP_001002611.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075981
      UniProtKB/Swiss-Prot
      A5PN41, Q6DHJ1
      Related
      ENSDARP00000055736.4, ENSDART00000055737.5
      Conserved Domains (1) summary
      pfam02676
      Location:9 → 193
      TYW3; Methyltransferase TYW3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      11119365..11126221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171159.5 → XP_005171216.1  tRNA wybutosine-synthesizing protein 3 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIJ6
      Conserved Domains (1) summary
      pfam02676
      Location:9 → 198
      TYW3; Methyltransferase TYW3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DHJ1.1 GenPept UniProtKB/Swiss-Prot:Q6DHJ1

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