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    ell elongation factor RNA polymerase II [ Danio rerio (zebrafish) ]

    Gene ID: 325221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ellprovided by ZNC
    Official Full Name
    elongation factor RNA polymerase IIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3946
    See related
    Ensembl:ENSDARG00000000568 AllianceGenome:ZFIN:ZDB-GENE-030131-3946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63836; wu:fc60b11
    Summary
    Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vasculogenesis. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Orthologous to human ELL (elongation factor for RNA polymerase II). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ell in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (20847587..20924564, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (20822609..20899586, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone Neighboring gene DOT1-like histone H3K79 methyltransferase Neighboring gene FKBP prolyl isomerase 8 Neighboring gene single stranded DNA binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. Zhou J, et al. J Biol Chem, 2009 Jul 10. PMID 19447890, Free PMC Article
    2. Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Song Y, et al. J Virol, 2023 Feb 28. PMID 36744960, Free PMC Article
    3. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. Ritter DI, et al. PLoS One, 2012. PMID 22567096, Free PMC Article
    4. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
      Title: Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II elongation factor ELL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199707.1 → NP_956001.1  RNA polymerase II elongation factor ELL

      See identical proteins and their annotated locations for NP_956001.1

      Status: PROVISIONAL

      Source sequence(s)
      BC058072
      UniProtKB/TrEMBL
      A0A8M1PBR6, F1QKC9, Q6PEG4
      Related
      ENSDARP00000091415.4, ENSDART00000100642.5
      Conserved Domains (2) summary
      pfam07303
      Location:528 → 625
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:6 → 279
      ELL; RNA polymerase II elongation factor ELL

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      20847587..20924564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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