pnpo pyridoxamine 5'-phosphate oxidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pnpoprovided by ZNC
Official Full Name: pyridoxamine 5'-phosphate oxidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060602-2
See related: Ensembl:ENSDARG00000017612 AllianceGenome:ZFIN:ZDB-GENE-060602-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7138360
Summary: Enables pyridoxamine phosphate oxidase activity. Involved in carboxylic acid metabolic process; pyridoxal biosynthetic process; and swimming behavior. Acts upstream of or within pyridoxal phosphate biosynthetic process. Is expressed in several structures, including digestive system; female organism; male organism; nervous system; and spleen. Used to study epilepsy and pyridoxamine 5'-phosphate oxidase deficiency. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (28799986..28807181)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (28685084..28692279)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors	IEA Inferred from Electronic Annotation more info
enables pyridoxamine phosphate oxidase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxamine phosphate oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyridoxal biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pyridoxine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: pyridoxine-5'-phosphate oxidase

Names: pyridoxine 5'-phosphate oxidase

NP_001243107.1

EC 1.4.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256178.1 → NP_001243107.1 pyridoxine-5'-phosphate oxidase

Status: VALIDATED

Source sequence(s)

BM035873, BX248092

UniProtKB/TrEMBL

A0A8M1P3D4

Related

ENSDARP00000011179.5, ENSDART00000022724.6

Conserved Domains (3) summary

TIGR00558
Location:74 → 277

pdxH; pyridoxamine-phosphate oxidase

pfam01243
Location:94 → 167

Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase

pfam10590
Location:223 → 277

PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region