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    pnpo pyridoxamine 5'-phosphate oxidase [ Danio rerio (zebrafish) ]

    Gene ID: 402868, updated on 9-Dec-2024

    Summary

    Official Symbol
    pnpoprovided by ZNC
    Official Full Name
    pyridoxamine 5'-phosphate oxidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060602-2
    See related
    Ensembl:ENSDARG00000017612 AllianceGenome:ZFIN:ZDB-GENE-060602-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7138360
    Summary
    Enables pyridoxamine phosphate oxidase activity. Involved in carboxylic acid metabolic process; pyridoxal biosynthetic process; and swimming behavior. Acts upstream of or within pyridoxal phosphate biosynthetic process. Is expressed in several structures, including digestive system; female organism; male organism; nervous system; and spleen. Used to study epilepsy and pyridoxamine 5'-phosphate oxidase deficiency. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See pnpo in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (28799986..28807181)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (28685084..28692279)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 7 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene proline rich 15 like b Neighboring gene CDK5 regulatory subunit associated protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    pyridoxine-5'-phosphate oxidase
    Names
    pyridoxine 5'-phosphate oxidase
    NP_001243107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256178.1NP_001243107.1  pyridoxine-5'-phosphate oxidase

      Status: VALIDATED

      Source sequence(s)
      BM035873, BX248092
      UniProtKB/TrEMBL
      A0A8M1P3D4
      Related
      ENSDARP00000011179.5, ENSDART00000022724.6
      Conserved Domains (3) summary
      TIGR00558
      Location:74277
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:94167
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:223277
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      28799986..28807181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394848.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      242463..249658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)