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    rab35b RAB35, member RAS oncogene family b [ Danio rerio (zebrafish) ]

    Gene ID: 445154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab35bprovided by ZNC
    Official Full Name
    RAB35, member RAS oncogene family bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-62
    See related
    Ensembl:ENSDARG00000058425 AllianceGenome:ZFIN:ZDB-GENE-040801-62
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rab35; sb:eu777; dZ146N9.2; zgc:100812; si:busm1-146n9.2
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Predicted to be active in endosome membrane and plasma membrane. Is expressed in Kupffer's vesicle and testis. Orthologous to human RAB35 (RAB35, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rab35b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (3649070..3674506)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (3590321..3615757)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene paxillin b Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene BICD family-like cargo adapter 1 Neighboring gene BICD family like cargo adaptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. Aljiboury AA, et al. PLoS Genet, 2023 May. PMID 37186603, Free PMC Article
    2. Rab35 controls cilium length, function and membrane composition. Kuhns S, et al. EMBO Rep, 2019 Oct 4. PMID 31432619, Free PMC Article
    3. Proteomic analysis of three gonad types of swamp eel reveals genes differentially expressed during sex reversal. Sheng Y, et al. Sci Rep, 2015 May 18. PMID 25985063, Free PMC Article
    4. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    5. A plasmid library of full-length zebrafish rab proteins for in vivo cell biology. Hall TE, et al. Cell Logist, 2017. PMID 28396820, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings demonstrate roles for Rab35 in regulating cilium length.
      Title: Rab35 controls cilium length, function and membrane composition.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-35b
    NP_001003548.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003548.2 → NP_001003548.1  ras-related protein Rab-35b

      See identical proteins and their annotated locations for NP_001003548.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077124
      UniProtKB/TrEMBL
      Q6DEJ0
      Related
      ENSDARP00000039450.6, ENSDART00000033152.7
      Conserved Domains (2) summary
      smart00175
      Location:9 → 170
      RAB; Rab subfamily of small GTPases
      cl21455
      Location:3 → 201
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      3649070..3674506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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