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    astn1 astrotactin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 791157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    astn1provided by ZNC
    Official Full Name
    astrotactin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-140
    See related
    Ensembl:ENSDARG00000068323 AllianceGenome:ZFIN:ZDB-GENE-050320-140
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:113405; zgc:158703
    Summary
    Predicted to be involved in neuron cell-cell adhesion and neuron migration. Predicted to be active in endosome and membrane. Used to study schizophrenia. Orthologous to human ASTN1 (astrotactin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See astn1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (34572889..34982401)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (34589679..34999941)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487979 Neighboring gene bone morphogenetic protein/retinoic acid inducible neural-specific 2 Neighboring gene uncharacterized LOC137487981 Neighboring gene uncharacterized LOC137487476 Neighboring gene pappalysin 2 Neighboring gene COP1 E3 ubiquitin ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Giousoh A, et al. Gene Expr Patterns, 2015 May-Jul. PMID 25981450
    2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113405

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    astrotactin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      34572889..34982401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003197882.6 → XP_003197930.4  astrotactin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RIG4

    2. XM_021467632.2 → XP_021323307.1  astrotactin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P116
      Conserved Domains (3) summary
      smart00457
      Location:820 → 1007
      MACPF; membrane-attack complex / perforin
      cd00063
      Location:1116 → 1158
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam14670
      Location:668 → 715
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_017351897.3 → XP_017207386.1  astrotactin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z1V4, F1Q5X4
      Related
      ENSDARP00000071684.5, ENSDART00000077216.6

    4. XM_017351899.3 → XP_017207388.1  astrotactin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YVX7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013561.1: Suppressed sequence

      Description
      NM_001013561.1: This RefSeq was temporarily suppressed because the CDS was partial.

    2. NM_001080639.1: Suppressed sequence

      Description
      NM_001080639.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ASTN1 (GeneID:460).
    Nucleotide Protein Strain
    Heading Accession and Version

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