tox thymocyte selection-associated high mobility group box [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: toxprovided by ZNC
Official Full Name: thymocyte selection-associated high mobility group boxprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-181
See related: Ensembl:ENSDARG00000032317 AllianceGenome:ZFIN:ZDB-GENE-070912-181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu868; si:ch211-198j13.2
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in leukocyte differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21982949..22105255)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (22324879..22447196)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOX is an HMG box-containing protein that has important roles in T-ALL initiation and maintenance. TOX inhibits the recruitment of KU70/KU80 to DNA breaks, thereby inhibiting NHEJ repair. Thus, TOX is likely a dominant oncogenic driver in a large fraction of human T-ALL and enhances genomic instability
Title: TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in leukocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymocyte selection-associated high mobility group box protein TOX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256694.1 → NP_001243623.1 thymocyte selection-associated high mobility group box protein TOX

Status: VALIDATED

Source sequence(s)

CR450692, CT956055

UniProtKB/TrEMBL

A0A2R8Q9T1, A0A8M1NZ21

Related

ENSDARP00000148167.1, ENSDART00000190722.1

Conserved Domains (1) summary

cd00084
Location:289 → 338

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

21982949..22105255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163360.4 → XP_005163417.1 thymocyte selection-associated high mobility group box protein TOX isoform X1

UniProtKB/TrEMBL

A0A8M2BAE1, B0V356

Related

ENSDARP00000044370.5, ENSDART00000044371.8

Conserved Domains (1) summary

cd00084
Location:288 → 337

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
XM_068224802.1 → XP_068080903.1 thymocyte selection-associated high mobility group box protein TOX isoform X2