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    slc22a2 solute carrier family 22 member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc22a2provided by ZNC
    Official Full Name
    solute carrier family 22 member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2167
    See related
    Ensembl:ENSDARG00000030530 AllianceGenome:ZFIN:ZDB-GENE-040426-2167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    oct1; zgc:64076; wu:fc01b11
    Summary
    Enables transmembrane transporter activity. Acts upstream of or within determination of heart left/right asymmetry. Located in plasma membrane. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to several human genes including SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc22a2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (42668902..42688487)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (42771792..42791377)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon CAG) Neighboring gene insulin-like growth factor 2 receptor Neighboring gene uncharacterized LOC137488688 Neighboring gene plasminogen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Visualizing the Brain's Astrocytes with Diverse Chemical Scaffolds. Preston AN, et al. ACS Chem Biol, 2018 Jun 15. PMID 29733639, Free PMC Article
    2. Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics. Mihaljević I, et al. Aquat Toxicol, 2017 Jun. PMID 28363126
    3. Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line. Thomas AJ, et al. J Neurosci, 2013 Mar 6. PMID 23467357, Free PMC Article
    4. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
    5. Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). Mihaljevic I, et al. BMC Genomics, 2016 Aug 12. PMID 27519738, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 22 member 2
    Names
    solute carrier family 22 (organic cation transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213150.1 → NP_998315.1  solute carrier family 22 member 2

      See identical proteins and their annotated locations for NP_998315.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054608
      UniProtKB/TrEMBL
      Q7T2C0
      Related
      ENSDARP00000048889.5, ENSDART00000048890.7
      Conserved Domains (2) summary
      cd06174
      Location:146 → 515
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12 → 525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      42668902..42688487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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