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    exd2 exonuclease 3'-5' domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 334455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exd2provided by ZNC
    Official Full Name
    exonuclease 3'-5' domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6387
    See related
    Ensembl:ENSDARG00000016117 AllianceGenome:ZFIN:ZDB-GENE-030131-6387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi72h12; wu:fi72h12; zgc:175195
    Summary
    Predicted to enable 3'-5' exonuclease activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See exd2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (51796668..51818675, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (51707633..51729650, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-168d23.3 Neighboring gene ornithine decarboxylase 1 Neighboring gene NUMB endocytic adaptor protein Neighboring gene FLVCR choline and putative heme transporter 2a Neighboring gene ergosterol biosynthesis 28 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatio-temporal mRNA tracking in the early zebrafish embryo. Holler K, et al. Nat Commun, 2021 Jun 7. PMID 34099733, Free PMC Article
    2. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    exonuclease 3'-5' domain-containing protein 2
    NP_001107878.1
    XP_005169949.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114406.1 → NP_001107878.1  exonuclease 3'-5' domain-containing protein 2

      See identical proteins and their annotated locations for NP_001107878.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159253
      UniProtKB/TrEMBL
      B0JZN3
      Related
      ENSDARP00000098875.1, ENSDART00000111389.4
      Conserved Domains (2) summary
      cd06141
      Location:83 → 263
      WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
      pfam14239
      Location:357 → 399
      RRXRR; RRXRR protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      51796668..51818675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169892.4 → XP_005169949.1  exonuclease 3'-5' domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BH75
      Conserved Domains (2) summary
      cd06141
      Location:83 → 258
      WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
      pfam14239
      Location:352 → 394
      RRXRR; RRXRR protein
    Nucleotide Protein
    Heading Accession and Version

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