mos v-mos Moloney murine sarcoma viral oncogene homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mosprovided by ZNC
Official Full Name: v-mos Moloney murine sarcoma viral oncogene homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040428-3
See related: Ensembl:ENSDARG00000069744 AllianceGenome:ZFIN:ZDB-GENE-040428-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: c-mos
Summary: Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of metaphase/anaphase transition of meiotic cell cycle; positive regulation of MAPK cascade; and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in blastomere and female organism. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (17098351..17099542, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (17162329..17163520, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Title: Formation of mos RNA granules in the zebrafish oocyte that differ from cyclin B1 RNA granules in distribution, density and regulation.
employed genetic linkage analysis and physical mapping to place the mosm188 mutation on chromosome 6 in the vicinity of the foxd3 gene
Title: The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene serine/threonine-protein kinase mos

NP_991143.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205580.1 → NP_991143.1 proto-oncogene serine/threonine-protein kinase mos

See identical proteins and their annotated locations for NP_991143.1

Status: PROVISIONAL

Source sequence(s)

AB032727

UniProtKB/TrEMBL

Q90YD0

Related

ENSDARP00000092499.3, ENSDART00000101724.5

Conserved Domains (2) summary

smart00220
Location:63 → 320

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13979
Location:56 → 329

STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

17098351..17099542 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

Range

215222..216413 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395321.1 Reference GRCz11 ALT_DRER_TU_2

Range

62383..63574 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001103195.1: Suppressed sequence

Description

NM_001103195.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.