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    spry4 sprouty homolog 4 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 114437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spry4provided by ZNC
    Official Full Name
    sprouty homolog 4 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010803-2
    See related
    Ensembl:ENSDARG00000068732 AllianceGenome:ZFIN:ZDB-GENE-010803-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb511; zSpry4; sprouty4; wu:fb92b06
    Summary
    Acts upstream of or within several processes, including negative regulation of fibroblast growth factor receptor signaling pathway; rhombomere formation; and skeletal muscle fiber development. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See spry4 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (44684577..44691071)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (44605062..44610571, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene microRNA mir-222b Neighboring gene transmembrane protein 164 Neighboring gene AMMECR nuclear protein 1 Neighboring gene kinesin family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Species-specific contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates. Steventon B, et al. Development, 2016 May 15. PMID 26989170
    2. Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Kizil C, et al. Dev Cell, 2012 Dec 11. PMID 23168169
    3. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee Y, et al. Development, 2005 Dec. PMID 16251209
    4. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Ishimatsu K, et al. Development, 2018 Jun 11. PMID 29769221, Free PMC Article
    5. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai Y, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754885, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
      Title: Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhombomere formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein sprouty homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131826.2 → NP_571901.2  protein sprouty homolog 4

      Status: VALIDATED

      Source sequence(s)
      CABZ01085217, EH447258
      UniProtKB/TrEMBL
      A0A8M9PQ80, F1QZW4, Q90XH4
      Related
      ENSDARP00000090302.3, ENSDART00000099528.4
      Conserved Domains (1) summary
      pfam05210
      Location:179 → 276
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      44684577..44691071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468746.2 → XP_021324421.1  protein sprouty homolog 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQ80, F1QZW4, Q90XH4
      Conserved Domains (1) summary
      pfam05210
      Location:179 → 276
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein Strain
    Heading Accession and Version

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