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    bco1 beta-carotene oxygenase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 84039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bco1provided by ZNC
    Official Full Name
    beta-carotene oxygenase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010508-1
    See related
    Ensembl:ENSDARG00000104256 AllianceGenome:ZFIN:ZDB-GENE-010508-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bcdo; bcox; bcdo1; bcmo1; b-diox; bcmo1a
    Summary
    Enables beta-carotene 15,15'-dioxygenase activity. Acts upstream of or within eye photoreceptor cell differentiation and hindbrain development. Is expressed in gut; liver; neural crest; ovary; and xanthophore. Orthologous to human BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bco1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (65272470..65290474)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (65048442..65066446)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 2a Neighboring gene beta-carotene oxygenase 1, like Neighboring gene bolA family member 3 Neighboring gene vesicle amine transport 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Photoreceptor morphology is severely affected in the beta,beta-carotene-15,15'-oxygenase (bcox) zebrafish morphant. Biehlmaier O, et al. Eur J Neurosci, 2005 Jan. PMID 15654843
    2. The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon. Helgeland H, et al. Gene, 2014 Jun 15. PMID 24583166
    3. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Kiefer C, et al. J Biol Chem, 2001 Apr 27. PMID 11278918
    4. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Wu M, et al. Aquat Toxicol, 2017 Nov. PMID 28992598
    5. Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. Saunders LM, et al. Elife, 2019 May 29. PMID 31140974, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-carotene 15,15'-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-carotene 15,15'-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables beta-carotene 15,15'-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carotenoid dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta,beta-carotene 15,15'-dioxygenase
    Names
    beta-carotene 15, 15'-dioxygenase
    beta-carotene 15,15'-monooxygenase 1a
    NP_001315424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328495.1 → NP_001315424.1  beta,beta-carotene 15,15'-dioxygenase

      Status: VALIDATED

      Source sequence(s)
      CU682354, CU856172
      UniProtKB/TrEMBL
      A0A8M1PAC3, Q7ZTS0
      Related
      ENSDARP00000137596.1, ENSDART00000162471.2
      Conserved Domains (1) summary
      pfam03055
      Location:10 → 513
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      65272470..65290474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131798.2: Suppressed sequence

      Description
      NM_131798.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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