ets1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ets1provided by ZNC
Official Full Name: v-ets avian erythroblastosis virus E26 oncogene homolog 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-021115-5
See related: Ensembl:ENSDARG00000024431 AllianceGenome:ZFIN:ZDB-GENE-021115-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb516; ets1a; id:ibd1116; zgc:110573
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within blood vessel development; regulation of DNA-templated transcription; and regulation of endothelial cell apoptotic process. Is expressed in several structures, including cardiovascular system; germ ring; mesoderm; nervous system; and neural crest. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (48276158..48324423, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (48283863..48329082, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes.
Title: Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes.
Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.
Title: Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.
Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish.
Title: Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel endothelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of endothelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein C-ets-1

Names: v-ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1a; v-ets erythroblastosis virus E26 oncogene-like 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.