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    ptrh2 peptidyl-tRNA hydrolase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 791795, updated on 9-Dec-2024

    Summary

    Official Symbol
    ptrh2provided by ZNC
    Official Full Name
    peptidyl-tRNA hydrolase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-163
    See related
    Ensembl:ENSDARG00000077339 AllianceGenome:ZFIN:ZDB-GENE-050522-163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj09f02; zgc:109954
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in negative regulation of anoikis and positive regulation of anoikis. Predicted to be located in membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ptrh2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28306747..28309313)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28420122..28422688)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496591 Neighboring gene uncharacterized LOC108191486 Neighboring gene clathrin, heavy chain a (Hc) Neighboring gene B-cell translocation gene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC109954, MGC173627

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity  
    enables aminoacyl-tRNA hydrolase activity  
    enables hydrolase activity  
    Process Evidence Code Pubs
    involved_in negative regulation of anoikis  
    involved_in positive regulation of anoikis  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in membrane  

    General protein information

    Preferred Names
    peptidyl-tRNA hydrolase 2, mitochondrial
    NP_001018371.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020535.2 → NP_001018371.2  peptidyl-tRNA hydrolase 2, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      CR392341
      UniProtKB/TrEMBL
      A0A8M1N623, F1Q6B2
      Related
      ENSDARP00000118511.1, ENSDART00000142016.2
      Conserved Domains (1) summary
      cd02430
      Location:62 → 176
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      28306747..28309313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394789.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      46134..48700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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