drosha drosha ribonuclease III [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: droshaprovided by ZNC
Official Full Name: drosha ribonuclease IIIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070209-23
See related: Ensembl:ENSDARG00000055563 AllianceGenome:ZFIN:ZDB-GENE-070209-23
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rnasen; im:7150667; zgc:158612
Summary: Predicted to enable ribonuclease III activity. Acts upstream of or within with a positive effect on primary miRNA processing. Acts upstream of or within angiogenesis. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (13344985..13389784)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (13306682..13351481)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosha associated with DGCR8, and both were required to cleave pri-miRNAs. The Drosha/DGCR8 holoenzyme preferred pri-miRNAs with a large terminal loop, an extended duplex region, and flanking single stranded RNAs.
Title: Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect primary miRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonuclease 3

Names: ribonuclease type III, nuclear

NP_001103942.1

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110472.1 → NP_001103942.1 ribonuclease 3

See identical proteins and their annotated locations for NP_001103942.1

Status: PROVISIONAL

Source sequence(s)

BC133134

UniProtKB/TrEMBL

A2RV16

Related

ENSDARP00000083450.4, ENSDART00000089017.5

Conserved Domains (6) summary

smart00358
Location:1181 → 1252

DSRM; Double-stranded RNA binding motif

PRK00102
Location:1025 → 1253

rnc; ribonuclease III; Reviewed

cd00593
Location:1042 → 1174

RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...

pfam08648
Location:204 → 320

DUF1777; Protein of unknown function (DUF1777)

pfam12871
Location:206 → 308

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

cl23807
Location:14 → 63

WWbp; WW-domain ligand protein