tcima transcriptional and immune response regulator a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcimaprovided by ZNC
Official Full Name: transcriptional and immune response regulator aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-36
See related: Ensembl:ENSDARG00000079497 AllianceGenome:ZFIN:ZDB-GENE-050320-36
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tc1a; fa99h09; wu:fa99h09; zgc:110340
Summary: Predicted to enable Notch binding activity. Predicted to be involved in endothelial cell activation involved in immune response and negative regulation of Notch signaling pathway. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; endothelial cell; epidermis; peripheral olfactory organ; and pharyngeal arch. Orthologous to human TCIM (transcriptional and immune response regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (27866649..27867657, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (27266496..27267504, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endothelial cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional and immune response regulator a

Names: thyroid cancer-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.