U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aanat1 arylalkylamine N-acetyltransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393677, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aanat1provided by ZNC
    Official Full Name
    arylalkylamine N-acetyltransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040329-1
    See related
    Ensembl:ENSDARG00000036567 AllianceGenome:ZFIN:ZDB-GENE-040329-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73074
    Summary
    Enables acetyltransferase activity. Predicted to be involved in circadian rhythm and response to light stimulus. Predicted to act upstream of or within melatonin biosynthetic process and rhythmic process. Predicted to be active in cytoplasm. Is expressed in brain; epiphysis; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See aanat1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (23616889..23619413, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (18518970..18521494, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911205 Neighboring gene uncharacterized LOC137495967 Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene uncharacterized LOC137495880

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock. Appelbaum L, et al. J Mol Endocrinol, 2006 Apr. PMID 16595704
    2. Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene-9-bisphenol in zebrafish (Danio rerio). Mi P, et al. J Pineal Res, 2019 Jan. PMID 30269372
    3. Melatonin is required for the circadian regulation of sleep. Gandhi AV, et al. Neuron, 2015 Mar 18. PMID 25754820, Free PMC Article
    4. A possible new role for fish retinal serotonin-N-acetyltransferase-1 (AANAT1): Dopamine metabolism. Zilberman-Peled B, et al. Brain Res, 2006 Feb 16. PMID 16427617
    5. Melatonin receptor agonist Piper betle L. ameliorates dexamethasone-induced early life stress in adult zebrafish. Kumari Y, et al. Exp Ther Med, 2019 Aug. PMID 31363378, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In constant darkness, the rhythmic expression of retinal aanat2 persisted while the aanat1 rhythm disappeared
      Title: Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC73074

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within melatonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serotonin N-acetyltransferase
    Names
    aanat1a
    NP_956998.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200704.1 → NP_956998.1  serotonin N-acetyltransferase

      See identical proteins and their annotated locations for NP_956998.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059448
      UniProtKB/TrEMBL
      Q6PC75, Q6V7J8
      Related
      ENSDARP00000053125.5, ENSDART00000053126.7
      Conserved Domains (2) summary
      COG0456
      Location:30 → 200
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:82 → 171
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      23616889..23619413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous