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    agbl5 AGBL carboxypeptidase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 445479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agbl5provided by ZNC
    Official Full Name
    AGBL carboxypeptidase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-29
    See related
    Ensembl:ENSDARG00000045900 AllianceGenome:ZFIN:ZDB-GENE-040822-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91997
    Summary
    Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Acts upstream of or within chordate embryonic development and cilium assembly. Predicted to be located in several cellular components, including cytosol; midbody; and mitotic spindle. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including Kupffer's vesicle; axis; forerunner cell group; nervous system; and pronephros. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See agbl5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (737539..760586, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (724091..747149, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:ch211-286m4.1 Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA tyrosine (anticodon GUA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development. Lyons PJ, et al. J Biol Chem, 2013 Oct 18. PMID 24022483, Free PMC Article
    2. Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Pathak N, et al. Mol Biol Cell, 2014 Jun 15. PMID 24743595, Free PMC Article
    3. Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization. D'Orazio FM, et al. Dev Cell, 2021 Mar 8. PMID 33651978, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ccp5 is the principal tubulin deglutamylase that maintains functional levels of cilia tubulin glutamylation.
      Title: Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
    2. These data suggest that CCP1 and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia.
      Title: Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branching point deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein deglutamylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein side chain deglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase-like protein 5
    Names
    ATP/GTP binding protein-like 5
    CCP5
    protein deglutamylase CCP5
    NP_001004113.1
    XP_017210489.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004113.1 → NP_001004113.1  cytosolic carboxypeptidase-like protein 5

      See identical proteins and their annotated locations for NP_001004113.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080248
      UniProtKB/Swiss-Prot
      Q68EI3
      Related
      ENSDARP00000094377.3, ENSDART00000103601.4
      Conserved Domains (1) summary
      cd06236
      Location:171 → 574
      M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      737539..760586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355000.3 → XP_017210489.1  cytosolic carboxypeptidase-like protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z5B1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EI3.1 GenPept UniProtKB/Swiss-Prot:Q68EI3

    Gene LinkOut

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