lims2 LIM and senescent cell antigen-like domains 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lims2provided by ZNC
Official Full Name: LIM and senescent cell antigen-like domains 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-56
See related: Ensembl:ENSDARG00000014976 AllianceGenome:ZFIN:ZDB-GENE-050522-56
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zeh0381; hm:zeh0381; zgc:112257; CH1073-55A19.1
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within heart contraction and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cell-cell junction; cytoplasm; and focal adhesion. Is expressed in adaxial cell; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to several human genes including LIMS1 (LIM zinc finger domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (94884..100619, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (116315..122010, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of either PINCH isoform independently leads to instability of ILK, loss of stretch-responsive anf and vegf expression, and progressive heart failure[PINCH2]
Title: PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM and senescent cell antigen-like-containing domain protein 2

Names: pinch2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.