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    nfu1 NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 403053, updated on 9-Dec-2024

    Summary

    Official Symbol
    nfu1provided by ZNC
    Official Full Name
    NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-365
    See related
    Ensembl:ENSDARG00000068125 AllianceGenome:ZFIN:ZDB-GENE-050417-365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hirip5; zgc:109711
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to act upstream of or within iron-sulfur cluster assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nfu1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49433663..49447946)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49444894..49459177)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-194e1.7 Neighboring gene synaptophysin b Neighboring gene opsin 7, group member d Neighboring gene RAS and EF-hand domain containing Neighboring gene FERM domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC109711

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
    Names
    HIRA interacting protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122708.1NP_001116180.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      BX957316
      UniProtKB/TrEMBL
      A0A8M1NGP8, B0S8L0
      Related
      ENSDARP00000114381.1, ENSDART00000140481.2
      Conserved Domains (2) summary
      smart00932
      Location:53140
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      pfam01106
      Location:167233
      NifU; NifU-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      49433663..49447946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)