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Syk spleen tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 20963, updated on 9-Dec-2024

Summary

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Official Symbol: Sykprovided by MGI
Official Full Name: spleen tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:99515
See related: Ensembl:ENSMUSG00000021457 AllianceGenome:MGI:99515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sykb
Summary: Enables several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of lymphocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 36.0), mammary gland adult (RPKM 7.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

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See Syk in Genome Data Viewer

Location:: 13 A5; 13 27.41 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (52736670..52802828)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (52582610..52648792)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence.
Title: SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence.
Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets.
Title: Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets.
Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/beta-catenin signaling.
Title: Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/β-catenin signaling.
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-kappaB pathway.
Title: Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets.
Title: Biochemical characterization of spleen tyrosine kinase (SYK) isoforms in platelets.
MiR-143 Targets SYK to Regulate NEFA Uptake and Contribute to Thermogenesis in Male Mice.
Title: MiR-143 Targets SYK to Regulate NEFA Uptake and Contribute to Thermogenesis in Male Mice.
Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets.
Title: Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets.
Neutrophil-Specific Syk Expression Is Crucial for Skin Disease in Experimental Epidermolysis Bullosa Acquisita.
Title: Neutrophil-Specific Syk Expression Is Crucial for Skin Disease in Experimental Epidermolysis Bullosa Acquisita.
Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets.
Title: Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets.
Syk Facilitates Influenza A Virus Replication by Restraining Innate Immunity at the Late Stage of Viral Infection.
Title: Syk Facilitates Influenza A Virus Replication by Restraining Innate Immunity at the Late Stage of Viral Infection.

Submit: New GeneRIF Correction See all GeneRIFs (186)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (3)
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables Toll-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables interleukin-15 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-15 receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within beta selection	IGI Inferred from Genetic Interaction more info	PubMed
involved_in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface pattern recognition receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lectin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to molecule of fungal origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of granulocyte macrophage colony-stimulating factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-3 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-3-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within leukotriene biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of granulocyte macrophage colony-stimulating factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-3 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of arachidonate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin secretion by platelet	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase SYK

NP_001185906.1

EC 2.7.10.2

NP_035648.2

EC 2.7.10.2

XP_006516958.1

EC 2.7.10.2

XP_006516960.1

EC 2.7.10.2

XP_017170960.1

EC 2.7.10.2

XP_036013851.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198977.1 → NP_001185906.1 tyrosine-protein kinase SYK

See identical proteins and their annotated locations for NP_001185906.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK049207, BC065121

Consensus CDS

CCDS26517.1

UniProtKB/Swiss-Prot

P48025

UniProtKB/TrEMBL

Q3UPF7, Q6P1E0

Related

ENSMUSP00000113852.2, ENSMUST00000120135.8

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
NM_011518.2 → NP_035648.2 tyrosine-protein kinase SYK

See identical proteins and their annotated locations for NP_035648.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BB629720, BC065121, U36776

Consensus CDS

CCDS26517.1

UniProtKB/Swiss-Prot

P48025

UniProtKB/TrEMBL

Q3UPF7, Q6P1E0

Related

ENSMUSP00000060828.7, ENSMUST00000055087.7

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

52736670..52802828

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516897.5 → XP_006516960.1 tyrosine-protein kinase SYK isoform X2

See identical proteins and their annotated locations for XP_006516960.1

UniProtKB/TrEMBL

Q6P1E0

Related

ENSMUSP00000112914.2, ENSMUST00000118756.8

Conserved Domains (3) summary

cd05116
Location:347 → 602

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_006516895.5 → XP_006516958.1 tyrosine-protein kinase SYK isoform X1

See identical proteins and their annotated locations for XP_006516958.1

UniProtKB/Swiss-Prot

P48025

UniProtKB/TrEMBL

Q3UPF7, Q6P1E0

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_036157958.1 → XP_036013851.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

Q6P1E0

Conserved Domains (3) summary

cd05116
Location:347 → 602

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_017315471.3 → XP_017170960.1 tyrosine-protein kinase SYK isoform X3

Conserved Domains (1) summary

cd05116
Location:97 → 352

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase