Arhgap39 Rho GTPase activating protein 39 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap39provided by MGI
Official Full Name: Rho GTPase activating protein 39provided by MGI
Primary source: MGI:MGI:107858
See related: Ensembl:ENSMUSG00000033697 AllianceGenome:MGI:107858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Porf-2; Kiaa1688; 9530053N22; D15Wsu169e
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in postsynapse organization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; ganglia; gut; nose; and skeletal musculature. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 13.3), colon adult (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.28 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76608183..76702366, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76723985..76818166, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Porf-2 is capable of binding to the EphB1 receptor, causing the outgrowth of axons to stop and retract upon EphB forward signal transduction within the axon growth cone.
Title: Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth.
Dendritic structures of CA1 pyramidal neurons were altered in Rho GTPase activating protein 39/Vilse homozygous knockout (Vilse(Delta/Delta) mice.
Title: Important roles of Vilse in dendritic architecture and synaptic plasticity.
Data suggest that preoptic regulatory factor-2 (Porf-2) may inhibit neural stem cell proliferation by enhancing p21 protein levels followed by G1 phase arrest.
Title: The RhoGAP domain-containing protein, Porf-2, inhibits proliferation and enhances apoptosis in neural stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Arb11 (e-PCR)
- UniSTS:239897

D15Wsu169e (e-PCR), detects polymorphism
- UniSTS:142029

AI843066 (e-PCR)
- UniSTS:164581

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 39

Names: preoptic regulatory factor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168288.2 → NP_001161760.2 rho GTPase-activating protein 39 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC156550

Consensus CDS

CCDS49654.2

UniProtKB/Swiss-Prot

P59281, Q69ZD4, Q6P9R6

Related

ENSMUSP00000158945.2, ENSMUST00000239003.2

Conserved Domains (2) summary

cd04389
Location:912 → 1097

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:759 → 900

MyTH4; MyTH4 domain
NM_001416281.1 → NP_001403210.1 rho GTPase-activating protein 39 isoform 3

Status: VALIDATED

Source sequence(s)

AC156550
NM_001416282.1 → NP_001403211.1 rho GTPase-activating protein 39 isoform 4

Status: VALIDATED

Source sequence(s)

AC156550

UniProtKB/TrEMBL

H7BX46
NM_001416283.1 → NP_001403212.1 rho GTPase-activating protein 39 isoform 4

Status: VALIDATED

Source sequence(s)

AC156550

UniProtKB/TrEMBL

H7BX46
NM_198420.3 → NP_940812.3 rho GTPase-activating protein 39 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC156550

Consensus CDS

CCDS27592.3

Related

ENSMUSP00000158984.2, ENSMUST00000239134.2

Conserved Domains (2) summary

cd04389
Location:881 → 1066

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:759 → 869

MyTH4; MyTH4 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

76608183..76702366 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248493.2 → XP_030104353.1 rho GTPase-activating protein 39 isoform X1

UniProtKB/TrEMBL

G3X932

Conserved Domains (2) summary

cd04389
Location:914 → 1099

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:762 → 903

MyTH4; MyTH4 domain
XM_030248494.2 → XP_030104354.1 rho GTPase-activating protein 39 isoform X2

UniProtKB/TrEMBL

H7BX46

Conserved Domains (2) summary

cd04389
Location:883 → 1068

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:762 → 872

MyTH4; MyTH4 domain
XM_036159348.1 → XP_036015241.1 rho GTPase-activating protein 39 isoform X1

UniProtKB/TrEMBL

G3X932

Conserved Domains (2) summary

cd04389
Location:914 → 1099

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:762 → 903

MyTH4; MyTH4 domain
XM_030248492.2 → XP_030104352.1 rho GTPase-activating protein 39 isoform X1

UniProtKB/TrEMBL

G3X932

Conserved Domains (2) summary

cd04389
Location:914 → 1099

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:762 → 903

MyTH4; MyTH4 domain
XM_006520794.4 → XP_006520857.1 rho GTPase-activating protein 39 isoform X1

See identical proteins and their annotated locations for XP_006520857.1

UniProtKB/TrEMBL

G3X932

Conserved Domains (2) summary

cd04389
Location:914 → 1099

RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...

pfam00784
Location:762 → 903

MyTH4; MyTH4 domain