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    Dck deoxycytidine kinase [ Mus musculus (house mouse) ]

    Gene ID: 13178, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dckprovided by MGI
    Official Full Name
    deoxycytidine kinaseprovided by MGI
    Primary source
    MGI:MGI:102726
    See related
    Ensembl:ENSMUSG00000029366 AllianceGenome:MGI:102726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables deoxyadenosine kinase activity. Involved in dAMP salvage. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; midbrain; nose; and telencephalon. Orthologous to human DCK (deoxycytidine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 26.6), liver E14.5 (RPKM 23.2) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Dck in Genome Data Viewer
    Location:
    5 E1; 5 43.96 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88912872..88931136)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88765013..88783277)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13577 Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:89195274-89195480 Neighboring gene MOB kinase activator 1B Neighboring gene predicted gene 15682 Neighboring gene STARR-seq mESC enhancer starr_13581 Neighboring gene solute carrier family 4 (anion exchanger), member 4 Neighboring gene makorin, ring finger protein 1, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_13582 Neighboring gene predicted gene, 35855

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables cytidine kinase activity  
    enables cytidine kinase activity  
    enables deoxyadenosine kinase activity PubMed 
    enables deoxyadenosine kinase activity  
    enables deoxycytidine kinase activity  
    enables deoxycytidine kinase activity  
    enables deoxycytidine kinase activity  
    enables deoxyguanosine kinase activity PubMed 
    enables deoxyribonucleoside binding  
    enables magnesium ion binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables pyrimidine deoxyribonucleoside binding  
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process  
    involved_in dAMP salvage PubMed 
    involved_in dGMP salvage PubMed 
    involved_in deoxycytidine metabolic process  
    involved_in nucleoside phosphate biosynthetic process  
    involved_in pyrimidine nucleotide metabolic process  
    involved_in pyrimidine nucleotide metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol PubMed 
    is_active_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    deoxycytidine kinase
    Names
    deoxyadenosine kinase
    deoxyguanosine kinase
    NP_031858.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007832.4NP_031858.1  deoxycytidine kinase

      See identical proteins and their annotated locations for NP_031858.1

      Status: VALIDATED

      Source sequence(s)
      BC060062, BU052737
      Consensus CDS
      CCDS19405.1
      UniProtKB/Swiss-Prot
      P43346
      UniProtKB/TrEMBL
      Q545E8, Q80US6
      Related
      ENSMUSP00000031311.10, ENSMUST00000031311.10
      Conserved Domains (2) summary
      COG0125
      Location:24257
      Tmk; Thymidylate kinase [Nucleotide transport and metabolism]
      pfam01712
      Location:24258
      dNK; Deoxynucleoside kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      88912872..88931136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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