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    Ecsit ECSIT signalling integrator [ Mus musculus (house mouse) ]

    Gene ID: 26940, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ecsitprovided by MGI
    Official Full Name
    ECSIT signalling integratorprovided by MGI
    Primary source
    MGI:MGI:1349469
    See related
    Ensembl:ENSMUSG00000066839 AllianceGenome:MGI:1349469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sitpec
    Summary
    Enables DNA-binding transcription factor activity and chromatin binding activity. Acts upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of transcription regulator complex. Is expressed in several structures, including egg cylinder; embryo mesoderm; and genitourinary system. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 41.2), kidney adult (RPKM 37.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ecsit in Genome Data Viewer
    Location:
    9 A3; 9 8.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21982731..21997648, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22071435..22086296, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene predicted gene, 16845 Neighboring gene STARR-positive B cell enhancer ABC_E8280 Neighboring gene predicted gene 6581 Neighboring gene calponin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway PubMed 
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway PubMed 
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway PubMed 
    involved_in innate immune response  
    involved_in innate immune response  
    acts_upstream_of_or_within mesoderm formation PubMed 
    involved_in regulation of oxidoreductase activity  
    involved_in regulation of oxidoreductase activity  
    involved_in regulation of protein complex stability  
    involved_in regulation of protein complex stability  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in toll-like receptor 4 signaling pathway  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    Names
    ECSIT homolog
    signaling intermediate in Toll pathway-evolutionarily conserved

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253897.2NP_001240826.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001240826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS22920.1
      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
      Related
      ENSMUSP00000136247.2, ENSMUST00000180180.8
      Conserved Domains (3) summary
      sd00004
      Location:126171
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:50266
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:269393
      ECSIT_C; C-terminal domain of the ECSIT protein
    2. NM_001253898.2NP_001240827.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001240827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS22920.1
      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
      Related
      ENSMUSP00000137424.2, ENSMUST00000179422.8
      Conserved Domains (3) summary
      sd00004
      Location:126171
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:50266
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:269393
      ECSIT_C; C-terminal domain of the ECSIT protein
    3. NM_001421174.1NP_001408103.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AC163623
      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
    4. NM_001421175.1NP_001408104.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AC163623
      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
    5. NM_012029.3NP_036159.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

      See identical proteins and their annotated locations for NP_036159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS22920.1
      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
      Related
      ENSMUSP00000096537.4, ENSMUST00000098937.10
      Conserved Domains (3) summary
      sd00004
      Location:126171
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:50266
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:269393
      ECSIT_C; C-terminal domain of the ECSIT protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21982731..21997648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242539.4XP_011240841.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      Conserved Domains (3) summary
      sd00004
      Location:126171
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:51266
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:269350
      ECSIT_C; C-terminal domain of the ECSIT protein
    2. XM_030244396.2XP_030100256.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      Conserved Domains (3) summary
      sd00004
      Location:56101
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:1196
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:199323
      ECSIT_C; C-terminal domain of the ECSIT protein
    3. XM_030244395.2XP_030100255.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      Conserved Domains (3) summary
      sd00004
      Location:56101
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:1196
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:199323
      ECSIT_C; C-terminal domain of the ECSIT protein
    4. XM_036155023.1XP_036010916.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      UniProtKB/TrEMBL
      A0A0R4J174
      Conserved Domains (3) summary
      sd00004
      Location:126171
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:50266
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:269393
      ECSIT_C; C-terminal domain of the ECSIT protein
    5. XM_011242540.4XP_011240842.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      Q91V53, Q9QZH6
      Conserved Domains (3) summary
      sd00004
      Location:56101
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:1196
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:199323
      ECSIT_C; C-terminal domain of the ECSIT protein
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