BIK1 botrytis-induced kinase1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BIK1
Official Full Name: botrytis-induced kinase1
Primary source: TAIR:AT2G39660
Locus tag: AT2G39660
See related: Araport:AT2G39660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: botrytis-induced kinase1; F12L6.32; F12L6_32
Summary: Encodes a plasma membrane-localized ser/thr protein kinase that is a crucial component of host response signaling required to activate the resistance responses to Botrytis and A. brassicicola infection. It is likely a negative regulator of salicylic acid accumulation and basal defense against virulent bacterial pathogens.
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Genomic context

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See BIK1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (16531527..16533986)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myosin XI-mediated BIK1 recruitment to nanodomains facilitates FLS2-BIK1 complex formation during innate immunity in Arabidopsis.
Title: Myosin XI-mediated BIK1 recruitment to nanodomains facilitates FLS2-BIK1 complex formation during innate immunity in Arabidopsis.
Phosphorylation of BIK1 is critical for interaction with downstream signaling components.
Title: Phosphorylation of BIK1 is critical for interaction with downstream signaling components.
study reveals the intertwined regulation of pattern recognition receptors (PRR) & receptor-like cytoplasmic kinase (RLCK) complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling
Title: Ligand-induced monoubiquitination of BIK1 regulates plant immunity.
This study unveiled unexpected differences in two closely related receptor systems and reports a new negative role of BIK1 in plant immunity.
Title: Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences.
Insect infestation mediated Botrytis Induced Kinase-1 (BIK1) induction resulted in inhibition of Phyto Alexin Deficient-4 (PAD4) protein. Lowered PAD4 triggers the plant defense mechanism, leading to degraded plant immune potential and thereby reducing the plant quality.
Title: Mathematical model for plant-insect interaction with dynamic response to PAD4-BIK1 interaction and effect of BIK1 inhibition.
These findings demonstrate the mechanistic basis of signal transduction from EFR to phytohormones, mediated through a EFR-BIK1-WRKY axis.
Title: The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity.
Purification, crystallization and X-ray diffraction analysis of BIK1 has been reported.
Title: Arabidopsis receptor-like cytoplasmic kinase BIK1: purification, crystallization and X-ray diffraction analysis.
Results demonstrate that BIK1 is a Pi starvation-responsive gene that functions as a negative regulator of Pi homeostasis in Arabidopsis.
Title: BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana.
These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death.
Title: BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death in Arabidopsis.
Data show that Xanthomonas oryzae pv. oryzae (Xoo) PXO99A XopR protein interacts with receptor-like cytoplasmic kinase BIK1 at the plasma membrane.
Title: A Xanthomonas oryzae pv. oryzae effector, XopR, associates with receptor-like cytoplasmic kinases and suppresses PAMP-triggered stomatal closure.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129522.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to fungus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: botrytis-induced kinase1

NP_181496.1

botrytis-induced kinase1 (BIK1); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid autophosphorylation, defense response to fungus, N-terminal protein myristoylation, response to fungus; LOCATED IN: nucleolus, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: PBS1-like 1 (TAIR:AT3G55450.1); Has 116707 Blast hits to 115355 proteins in 4256 species: Archae - 101; Bacteria - 13366; Metazoa - 43229; Fungi - 9583; Plants - 33164; Viruses - 356; Other Eukaryotes - 16908 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16531527..16533986

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129522.5 → NP_181496.1 botrytis-induced kinase1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181496.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48814

UniProtKB/TrEMBL

A0A178VYW0, A0A5S9X5K1

Conserved Domains (1) summary

cd14066
Location:73 → 352

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs