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    CYP71A12 cytochrome P450 family 71 polypeptide [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817626, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP71A12
    Official Full Name
    cytochrome P450 family 71 polypeptide
    Primary source
    TAIR:AT2G30750
    Locus tag
    AT2G30750
    See related
    Araport:AT2G30750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; family 71; polypeptide 12; subfamily A; T11J7.14; T11J7_14
    Summary
    putative cytochrome P450
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    Genomic context

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    See CYP71A12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (13099486..13101371, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cytochrome P450 family 71 polypeptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of CYP71A12 monooxygenase in pathogen-triggered tryptophan metabolism and Arabidopsis immunity. Pastorczyk M, et al. New Phytol, 2020 Jan. PMID 31411742
    2. TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASE-Mediated Generation and Metabolic Analysis of Camalexin-Deficient cyp71a12 cyp71a13 Double Knockout Lines. Müller TM, et al. Plant Physiol, 2015 Jul. PMID 25953104, Free PMC Article
    3. The Formation of a Camalexin Biosynthetic Metabolon. Mucha S, et al. Plant Cell, 2019 Nov. PMID 31511315, Free PMC Article
    4. Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. Nafisi M, et al. Plant Cell, 2007 Jun. PMID 17573535, Free PMC Article
    5. Metabolic and transcriptomic changes induced in Arabidopsis by the rhizobacterium Pseudomonas fluorescens SS101. van de Mortel JE, et al. Plant Physiol, 2012 Dec. PMID 23073694, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of CYP71A12 monooxygenase in pathogen-triggered tryptophan metabolism and Arabidopsis immunity.
      Title: The role of CYP71A12 monooxygenase in pathogen-triggered tryptophan metabolism and Arabidopsis immunity.
    2. In contrast to cyp71a13 plants, in which camalexin accumulation is partially reduced, double mutants synthesized only traces of camalexin, demonstrating that CYP71A12 contributes to camalexin biosynthesis in leaf tissue.
      Title: TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASE-Mediated Generation and Metabolic Analysis of Camalexin-Deficient cyp71a12 cyp71a13 Double Knockout Lines.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128628.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within induced systemic resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 family 71 polypeptide
    NP_180633.3
    • cytochrome P450, family 71, subfamily A, polypeptide 12 (CYP71A12); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: response to bacterium; LOCATED IN: endomembrane system; EXPRESSED IN: stem, stamen; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 71, subfamily A, polypeptide 13 (TAIR:AT2G30770.1); Has 34196 Blast hits to 33993 proteins in 1718 species: Archae - 48; Bacteria - 4046; Metazoa - 11921; Fungi - 7292; Plants - 9674; Viruses - 3; Other Eukaryotes - 1212 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13099486..13101371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128628.4 → NP_180633.3  cytochrome P450 family 71 polypeptide [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4INX7, O49340, Q8LPP9
      UniProtKB/TrEMBL
      A0A178VN27, A0A5S9X2U8, A0A654EXK9
      Conserved Domains (1) summary
      cd11072
      Location:63 → 489
      CYP71-like; cytochrome P450 family 71 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49340.1

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