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    RPA2 replicon protein A2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816985, updated on 3-Oct-2024

    Summary

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    Official Symbol
    RPA2
    Official Full Name
    replicon protein A2
    Primary source
    TAIR:AT2G24490
    Locus tag
    AT2G24490
    See related
    Araport:AT2G24490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRPA2; ATRPA32A; replicon protein A2; ROR1; RPA32A; SUPPRESSOR OF ROS1; T28I24.22; T28I24_22
    Summary
    Encodes a component of Replication Protein A. Component of transcriptional gene silencing which does not affect endogenous small RNA accumulation nor DNA methylation. Localized in the nucleus. Involved in DNA repair. Interacts physically with ROS1.
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    Genomic context

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    See RPA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (10397377..10400802, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene filament-like protein (DUF869) Neighboring gene Zinc finger, C3HC4 type (RING finger) family protein Neighboring gene Zinc finger protein 622 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division. Yang K, et al. Proc Natl Acad Sci U S A, 2019 Sep 3. PMID 31431532, Free PMC Article
    2. Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication. Elmayan T, et al. Curr Biol, 2005 Nov 8. PMID 16271868
    3. PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis. Meng J, et al. New Phytol, 2024 Nov. PMID 39229867
    4. ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. Xia R, et al. Plant Cell, 2006 Jan. PMID 16326925, Free PMC Article
    5. Mutations in a conserved replication protein suppress transcriptional gene silencing in a DNA-methylation-independent manner in Arabidopsis. Kapoor A, et al. Curr Biol, 2005 Nov 8. PMID 16271867

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis.
      Title: PRL1 interacts with and stabilizes RPA2A to regulate carbon deprivation-induced senescence in Arabidopsis.
    2. study provides a mechanistic understanding of the CDK-mediated phosphorylation of RPA in the precise control of cell cycle and DNA repair in plants.
      Title: A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division.
    3. Results suggest important roles for ROR1/RPA2A in epigenetic gene silencing and in the regulation of plant development.
      Title: ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis.
    4. Arabidopsis RPA2 is a genetic link between transcriptional gene silencing, DNA repair, and DNA replication.
      Title: Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication.
    5. At2g24490 is the RPA2 gene, which plays an essential role in the maintenance of transcriptional gene silencing at specific loci in a DNA-methylation-independent manner.
      Title: Mutations in a conserved replication protein suppress transcriptional gene silencing in a DNA-methylation-independent manner in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001124904.1
    NM_128010.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    replicon protein A2
    NP_001118376.1
    • replicon protein A2 (RPA2); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Replication protein A, subunit RPA32 (InterPro:IPR014646), Replication protein A, C-terminal (InterPro:IPR014892), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); BEST Arabidopsis thaliana protein match is: Replication protein A, subunit RPA32 (TAIR:AT3G02920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_565571.1
    • replicon protein A2 (RPA2); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Replication protein A, subunit RPA32 (InterPro:IPR014646), Replication protein A, C-terminal (InterPro:IPR014892), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); BEST Arabidopsis thaliana protein match is: Replication protein A, subunit RPA32 (TAIR:AT3G02920.1); Has 524 Blast hits to 524 proteins in 181 species: Archae - 0; Bacteria - 0; Metazoa - 245; Fungi - 127; Plants - 108; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10397377..10400802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001124904.1 → NP_001118376.1  replicon protein A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118376.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZQ19
      UniProtKB/TrEMBL
      A0A178VTA7, A0A5S9X106
      Conserved Domains (2) summary
      cd04478
      Location:72 → 165
      RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      pfam08784
      Location:163 → 272
      RPA_C; Replication protein A C terminal

    2. NM_128010.3 → NP_565571.1  replicon protein A2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZQ19
      UniProtKB/TrEMBL
      A0A178VTA7, A0A5S9X106
      Conserved Domains (2) summary
      cd04478
      Location:72 → 165
      RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      pfam08784
      Location:163 → 272
      RPA_C; Replication protein A C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZQ19.2

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