ALD1 AGD2-like defense response protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ALD1
Official Full Name: AGD2-like defense response protein 1
Primary source: TAIR:AT2G13810
Locus tag: AT2G13810
See related: Araport:AT2G13810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AGD2-like defense response protein 1; AtALD1; eds two suppressor 5; EDTS5; F17L24.14
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Genomic context

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See ALD1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 10

Sequence:: Chromosome: 2; NC_003071.7 (5768417..5772266)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity.
Title: AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity.
ALD1 accumulation in Arabidopsis epidermal plastids confers local and non-autonomous disease resistance.
Title: ALD1 accumulation in Arabidopsis epidermal plastids confers local and non-autonomous disease resistance.
Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes.
Title: Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes.
A positive regulatory loop consisting of MPK3/MPK6, WRKY33, ALD1, and pipecolic acid in systemic acquired resistance induction .WRKY33 binds to the ALD1 promoter.
Title: A MPK3/6-WRKY33-ALD1-Pipecolic Acid Regulatory Loop Contributes to Systemic Acquired Resistance.
The structure of ALD1 from the flowering plant Arabidopsis thaliana (AtALD1) was solved at a resolution of 2.3 A.
Title: Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.
ALD1 plays important roles in edr2-mediated defense responses, and senescence and revealed a crosstalk between ethylene and salicylic acid signaling mediated by ALD1 and EDR2.
Title: Suppression of edr2-mediated powdery mildew resistance, cell death and ethylene-induced senescence by mutations in ALD1 in Arabidopsis.
ALD1 is partially required for Pseudomonas syringae HopW1-1-induced disease resistance.
Title: Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1.
We now find agd2-like defense response protein1 to be a key defense component that acts in multiple contexts and partially requires the PHYTOALEXIN DEFICIENT4 (PAD4) defense regulatory gene for its expression in response to infection. [ALD1]
Title: A key role for ALD1 in activation of local and systemic defenses in Arabidopsis.

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Pathways from PubChem

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General gene information

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NM_126957.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables L-lysine alpha-aminotransferase	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables transaminase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-pipecolic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IDA Inferred from Direct Assay more info	PubMed
involved_in systemic acquired resistance, salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AGD2-like defense response protein 1

NP_565359.1

AGD2-like defense response protein 1 (ALD1); FUNCTIONS IN: transferase activity, transferring nitrogenous groups, pyridoxal phosphate binding, transaminase activity, catalytic activity; INVOLVED IN: asparagine catabolic process, biosynthetic process, glutamate catabolic process to oxaloacetate, aspartate transamidation; LOCATED IN: chloroplast; EXPRESSED IN: sepal, root, stamen; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: LL-diaminopimelate aminotransferase, plant-related (InterPro:IPR019942), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT4G33680.1); Has 32741 Blast hits to 32741 proteins in 2900 species: Archae - 975; Bacteria - 23252; Metazoa - 372; Fungi - 435; Plants - 591; Viruses - 0; Other Eukaryotes - 7116 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

5768417..5772266

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126957.2 → NP_565359.1 AGD2-like defense response protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565359.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93ZH8, Q9ZQI7

UniProtKB/TrEMBL

A0A178VQ02, A0A7G2E893

Conserved Domains (1) summary

PRK07590
Location:40 → 437

PRK07590; L,L-diaminopimelate aminotransferase; Validated