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    AAP8 amino acid permease 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837536, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAP8
    Official Full Name
    amino acid permease 8
    Primary source
    TAIR:AT1G10010
    Locus tag
    AT1G10010
    See related
    Araport:AT1G10010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    amino acid permease 8; ATAAP8; T27I1.3; T27I1_3
    Summary
    Encodes a high affinity amino acid transporter that is probably responsible for import of organic nitrogen into developing seeds. One of eight gene family members that encode amino acid permeases. Most closely related to AAP1 (75%) identity.
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    Genomic context

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    See AAP8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (3265886..3268823)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNA repair DEAD helicase RAD3/XP-D subfamily protein Neighboring gene Ribonuclease H-like superfamily protein Neighboring gene formin-like protein (DUF1005) Neighboring gene ergosterol biosynthesis protein Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids. Santiago JP, et al. Plant Physiol, 2016 May. PMID 27016446, Free PMC Article
    2. The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana. Schmidt R, et al. Planta, 2007 Sep. PMID 17476526
    3. High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis. Okumoto S, et al. J Biol Chem, 2002 Nov 22. PMID 12244056
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAP8 is important for the import of neutral and acidic amino acids into the phloem, but does not play a role in seed nitrogen filling.
      Title: Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids.
    2. crucial role for the uptake of amino acids into the endosperm and supplying the developing embryo with amino acids during early embryogenesis
      Title: The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    amino acid permease 8
    NP_172472.1
    • amino acid permease 8 (AAP8); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: amino acid permease 1 (TAIR:AT1G58360.1); Has 2959 Blast hits to 2943 proteins in 246 species: Archae - 0; Bacteria - 24; Metazoa - 771; Fungi - 529; Plants - 1378; Viruses - 0; Other Eukaryotes - 257 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3265886..3268823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331877.1 → NP_001322343.1  amino acid permease 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATS1, A0A5S9TKZ7

    2. NM_100875.1 → NP_172472.1  amino acid permease 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80592
      UniProtKB/TrEMBL
      A0A5S9TKZ7
      Conserved Domains (2) summary
      COG0814
      Location:39 → 462
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam01490
      Location:28 → 462
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80592.1

    Gene LinkOut

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