ADL6 dynamin-like protein 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: ADL6
Official Full Name: dynamin-like protein 6
Primary source: TAIR:AT1G10290
Locus tag: AT1G10290
See related: Araport:AT1G10290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DRP2A; dynamin-like protein 6; DYNAMIN-RELATED PROTEIN 2A; F14N23.17; F14N23_17
Summary: involved in trafficking from the trans-Golgi Network to the central vacuole.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ADL6 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 22

Sequence:: Chromosome: 1; NC_003070.9 (3370402..3377463)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. [DRP2A]
Title: Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2.
DRP2A and DRP2B function coordinately in multiple pathways of post-Golgi trafficking in phosphatidylinositol 3- or 4-kinase and cytoskeleton polymerization-dependent manners
Title: Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking.
Data support a role for DRP2A/B in endocytosis and demonstrate that the function of at least one of these closely related proteins is essential for plant growth.
Title: A role for Arabidopsis dynamin related proteins DRP2A/B in endocytosis; DRP2 function is essential for plant growth.
drp2ab double mutants undergo an early developmental arrest prior to the first mitotic cell division during both male and female gametophytic development, resulting in gametophytic lethality.
Title: The Arabidopsis dynamin-related protein2 family is essential for gametophyte development.
Based on these results we propose that Seh1 plays a role in regulating cycling of DRP2A between membrane-bound and soluble forms.
Title: A WD40 repeat protein, Arabidopsis Sec13 homolog 1, may play a role in vacuolar trafficking by controlling the membrane association of AtDRP2A.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_100903.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in extracellular region	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: dynamin-like protein 6

NP_172500.1

dynamin-like protein 6 (ADL6); FUNCTIONS IN: GTPase activity; INVOLVED IN: Golgi to vacuole transport; LOCATED IN: Golgi apparatus, plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Pleckstrin homology-type (InterPro:IPR011993), Dynamin, GTPase region, conserved site (InterPro:IPR019762), Dynamin, GTPase domain (InterPro:IPR001401), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: dynamin-like 3 (TAIR:AT1G59610.1); Has 3284 Blast hits to 3098 proteins in 352 species: Archae - 4; Bacteria - 126; Metazoa - 1435; Fungi - 709; Plants - 704; Viruses - 0; Other Eukaryotes - 306 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

3370402..3377463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100903.4 → NP_172500.1 dynamin-like protein 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172500.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WPR7, Q56YX7, Q9SE83, Q9SY71

UniProtKB/TrEMBL

A0A178WBB3, A0A7G2DUE4

Conserved Domains (4) summary

cd08771
Location:41 → 303

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

smart00233
Location:577 → 696

PH; Pleckstrin homology domain

pfam01031
Location:371 → 494

Dynamin_M; Dynamin central region

cl02558
Location:737 → 810

GED; Dynamin GTPase effector domain