U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HSP20-like chaperones superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841923, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    HSP20-like chaperones superfamily protein
    Primary source
    TAIR:AT1G54840
    Locus tag
    AT1G54840
    See related
    Araport:AT1G54840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    IDM2; increased DNA methylation 2; T22H22.23; T22H22_23
    Summary
    Encodes an atypical member of the sHSP20 family that is involved in histone demethylation. Loss of function mutations show increased methylation. IMD2 co-localizes to the nucleus with, and physically interacts with, IMD1, a protein involved in RNA directed DNA methylation. IMD2 contains an alpha crystallin domain, that is required for its function.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (20452593..20454266, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene nuclear factor Y, subunit C3 Neighboring gene ncRNA Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene Glycoprotein membrane precursor GPI-anchored

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis. Wang C, et al. Plant Physiol, 2015 Mar. PMID 25593350, Free PMC Article
    2. Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Qian W, et al. Mol Cell, 2014 Aug 7. PMID 25002145, Free PMC Article
    3. REPRESSOR OF SILENCING5 Encodes a Member of the Small Heat Shock Protein Family and Is Required for DNA Demethylation in Arabidopsis. Zhao Y, et al. Plant Cell, 2014 Jun. PMID 24920332, Free PMC Article
    4. Regulation of Active DNA Demethylation by a Methyl-CpG-Binding Domain Protein in Arabidopsis thaliana. Li Q, et al. PLoS Genet, 2015 May. PMID 25933434, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that IDM2 functions in active DNA demethylation and in antisilencing by regulating IDM1.
      Title: Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    NM_104357.5
    NM_202302.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    HSP20-like chaperones superfamily protein
    NP_175881.2
    • HSP20-like chaperones superfamily protein; CONTAINS InterPro DOMAIN/s: Heat shock protein Hsp20 (InterPro:IPR002068), HSP20-like chaperone (InterPro:IPR008978); BEST Arabidopsis thaliana protein match is: HSP20-like chaperones superfamily protein (TAIR:AT1G54850.1); Has 96 Blast hits to 86 proteins in 17 species: Archae - 0; Bacteria - 13; Metazoa - 0; Fungi - 0; Plants - 83; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_974031.1
    • HSP20-like chaperones superfamily protein; BEST Arabidopsis thaliana protein match is: HSP20-like chaperones superfamily protein (TAIR:AT1G20870.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20452593..20454266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104357.5 → NP_175881.2  HSP20-like chaperones superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175881.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYL2, Q8RWL4, Q9ZVL2
      UniProtKB/TrEMBL
      A0A178W270, A0A5S9WPR4, A0A654EJY8
      Conserved Domains (1) summary
      cd06464
      Location:244 → 342
      ACD_sHsps-like; Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally ...

    2. NM_202302.2 → NP_974031.1  HSP20-like chaperones superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWL4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWL4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools