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    AtCaN2 Ca(2+)-dependent nuclease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818634, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AtCaN2
    Official Full Name
    Ca(2+)-dependent nuclease family protein
    Primary source
    TAIR:AT2G40410
    Locus tag
    AT2G40410
    See related
    Araport:AT2G40410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Ca2+-dependent nuclease; calcium dependent nuclease 2; CAN2; T3G21.18; T3G21_18
    Summary
    Encodes a Ca(2+)-dependent nuclease that can degrade both DNA and RNA.
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    Genomic context

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    See AtCaN2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (16873345..16875692)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene neuronal PAS domain protein Neighboring gene DUF399 family protein, putative (DUF399 and DUF3411) Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene Nop53 protein Neighboring gene transcription factor SCREAM-like protein Neighboring gene BTB/POZ domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression, and characterization of a Ca2+-dependent nuclease of Arabidopsis thaliana. Guo K, et al. Protein Expr Purif, 2012 May. PMID 22450164
    2. Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases. Leśniewicz K, et al. BMC Plant Biol, 2012 Oct 26. PMID 23102437, Free PMC Article
    3. Arabidopsis cysteine proteinase inhibitor AtCYSb interacts with a Ca(2+)-dependent nuclease, AtCaN2. Guo K, et al. FEBS Lett, 2013 Nov 1. PMID 24076026
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Arabidopsis staphylococcal-like nucleases, named CAN1 and CAN2, are anchored to the cell membrane via N-terminal myristoylation and palmitoylation modifications.[CAN2]
      Title: Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases.
    2. The protein encoded by AT2G40410 (CAN2) is a Ca2+-dependent and Zn2+-sensitive nuclease which preferentially degrades ssDNA and RNA at neutral pH. This protein possesses a unique hybrid structure in their catalytic domain consisting of staphylococcal nuclease-like and tRNA synthetase anticodon binding-like motifs. Microarray experiments show that CAN2 nuclease is constitutively expressed in plant tissues.
      Title: Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336837.1
    NM_201920.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Ca(2+)-dependent nuclease family protein
    NP_001318389.1
    • Staphylococcal nuclease homologue; FUNCTIONS IN: nuclease activity; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: Ca-2+ dependent nuclease (TAIR:AT3G56170.1); Has 74 Blast hits to 74 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 74; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_973649.1
    • Staphylococcal nuclease homologue; FUNCTIONS IN: hydrolase activity, acting on ester bonds, nuclease activity, nucleic acid binding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Staphylococcal nuclease (SNase-like) (InterPro:IPR006021), Staphylococcal nuclease (SNase-like), OB-fold (InterPro:IPR016071); BEST Arabidopsis thaliana protein match is: Ca-2+ dependent nuclease (TAIR:AT3G56170.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16873345..16875692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201920.3 → NP_973649.1  Ca(2+)-dependent nuclease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IH31, Q8RWK9, Q9SIY4
      UniProtKB/TrEMBL
      A0A178VMC2, A0A5S9X5R0
      Conserved Domains (1) summary
      pfam00565
      Location:221 → 316
      SNase; Staphylococcal nuclease homolog

    2. NM_001336837.1 → NP_001318389.1  Ca(2+)-dependent nuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZE34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IH31.1

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