U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RDR1 RNA-dependent RNA polymerase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838044, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RDR1
    Official Full Name
    RNA-dependent RNA polymerase 1
    Primary source
    TAIR:AT1G14790
    Locus tag
    AT1G14790
    See related
    Araport:AT1G14790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtRDR1; ATRDRP1; F10B6.19; F10B6_19; RNA-dependent RNA polymerase 1
    Summary
    Encodes RNA-dependent RNA polymerase. While not required for virus-induced post-transcriptional gene silencing (PTGS), it can promote turnover of viral RNAs in infected plants. Nomenclature according to Xie, et al. (2004). Involved in the production of Cucumber Mosaic Virus siRNAs.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RDR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (5093961..5098270, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene S locus-related glycoprotein 1 (SLR1) binding pollen coat protein family Neighboring gene KNOX meinox protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene MAC/Perforin domain-containing protein Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene semialdehyde dehydrogenase family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role of hydrogen peroxide and nitric oxide in the induction of plant-encoded RNA-dependent RNA polymerase 1 in the basal defense against Tobacco mosaic virus. Liao YW, et al. PLoS One, 2013. PMID 24098767, Free PMC Article
    2. Expressional and regulatory characterization of Arabidopsis RNA-dependent RNA polymerase 1. Xu T, et al. Planta, 2013 Jun. PMID 23503757
    3. Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection. Garcia-Ruiz H, et al. Plant Cell, 2010 Feb. PMID 20190077, Free PMC Article
    4. Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs. Diaz-Pendon JA, et al. Plant Cell, 2007 Jun. PMID 17586651, Free PMC Article
    5. Analysis of the involvement of an inducible Arabidopsis RNA-dependent RNA polymerase in antiviral defense. Yu D, et al. Mol Plant Microbe Interact, 2003 Mar. PMID 12650452

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In response to Tobacco mosaic virus infection, H2O2 acts downstream of NO to mediate induction of RDR1, which plays a critical role in strengthening RNA silencing to restrict systemic viral infection.
      Title: The role of hydrogen peroxide and nitric oxide in the induction of plant-encoded RNA-dependent RNA polymerase 1 in the basal defense against Tobacco mosaic virus.
    2. AtRDR1-associated pathogen defense is conducted mainly in the plant vascular tissue system and is under complex regulation.
      Title: Expressional and regulatory characterization of Arabidopsis RNA-dependent RNA polymerase 1.
    3. Components of the RNA-silencing machinery, RNA-DEPENDENT RNA POLYMERASE1 and SUPPRESSOR OF GENE SILENCING3 were isolated, implicating RNA silencing in the control of cuticular wax deposition during inflorescence stem development in Arabidopsis .
      Title: RDR1 and SGS3, components of RNA-mediated gene silencing, are required for the regulation of cuticular wax biosynthesis in developing inflorescence stems of Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_101348.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA-dependent RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNA-dependent RNA polymerase 1
    NP_172932.1
    • RNA-dependent RNA polymerase 1 (RDR1); CONTAINS InterPro DOMAIN/s: RNA-dependent RNA polymerase, eukaryotic-type (InterPro:IPR007855); BEST Arabidopsis thaliana protein match is: RNA-dependent RNA polymerase 2 (TAIR:AT4G11130.1); Has 638 Blast hits to 623 proteins in 115 species: Archae - 0; Bacteria - 2; Metazoa - 73; Fungi - 286; Plants - 205; Viruses - 2; Other Eukaryotes - 70 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5093961..5098270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101348.4 → NP_172932.1  RNA-dependent RNA polymerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1K9, Q9LQV2, Q9ZRX5
      UniProtKB/TrEMBL
      A0A178WKG4, A0A5S9UGA6, A0A654EAY4
      Conserved Domains (2) summary
      pfam05183
      Location:379 → 931
      RdRP; RNA dependent RNA polymerase
      cl17169
      Location:5 → 87
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQV2.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools