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    SUB Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837654, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUB
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT1G11130
    Locus tag
    AT1G11130
    See related
    Araport:AT1G11130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT1G11140; SCM; SCRAMBLED; SRF9; STRUBBELIG; STRUBBELIG-RECEPTOR FAMILY 9; T19D16.8
    Summary
    Encodes a receptor-like kinase protein with a predicted extracellular domain of six leucine-rich repeats and an intracellular serine-threonine kinase domain expressed throughout the developing root. Regulates expression of GLABRA2, CAPRICE, WEREWOLF, and ENHANCER OF GLABRA3. Required for floral organ shape, the development of the outer integument of ovules, and stem development. Regulates cell shape and cell division planes in the L2 layer of floral meristems and the L1-derived outer integument of ovules. Controls specification of epidermal root hairs. Participates in the coordination of cell morphogenesis between cell layers during floral development.
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    Genomic context

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    See SUB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (3722708..3727450)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene CTTNBP 2 amino-terminal-like protein Neighboring gene uncharacterized protein Neighboring gene hypothetical protein (DUF674) Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis receptor kinase STRUBBELIG regulates the response to cellulose deficiency. Chaudhary A, et al. PLoS Genet, 2020 Jan. PMID 31961852, Free PMC Article
    2. Positional signaling mediated by a receptor-like kinase in Arabidopsis. Kwak SH, et al. Science, 2005 Feb 18. PMID 15618487
    3. STRUBBELIG defines a receptor kinase-mediated signaling pathway regulating organ development in Arabidopsis. Chevalier D, et al. Proc Natl Acad Sci U S A, 2005 Jun 21. PMID 15951420, Free PMC Article
    4. The role of the SCRAMBLED receptor-like kinase in patterning the Arabidopsis root epidermis. Kwak SH, et al. Dev Biol, 2007 Feb 1. PMID 17027738
    5. The Arabidopsis receptor-like kinase STRUBBELIG mediates inter-cell-layer signaling during floral development. Yadav RK, et al. Dev Biol, 2008 Nov 15. PMID 18771664

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis MCTP family member QUIRKY regulates the formation of the STRUBBELIG receptor kinase complex.
      Title: Arabidopsis MCTP family member QUIRKY regulates the formation of the STRUBBELIG receptor kinase complex.
    2. SUB controls tissue morphogenesis and the response to cell wall damage.
      Title: The Arabidopsis receptor kinase STRUBBELIG regulates the response to cellulose deficiency.
    3. SUB is mis-targeted in hap13-1. However, unlike that of PIN2, the distribution of PIN1 is independent of HAP13. Genetic interference of exocytic trafficking at the TGN/EE by specifically downregulating HAP13 phenocopied the defects of hap13-1 in SUB targeting and ovule development.
      Title: HAPLESS13-Mediated Trafficking of STRUBBELIG Is Critical for Ovule Development in Arabidopsis.
    4. These results suggest that the AN protein is one of the critical downstream factors of SCM pathways specifically responsible for mediating its effects on cell/tissue morphogenesis through cortical microtubule arrangement.
      Title: ANGUSTIFOLIA mediates one of the multiple SCRAMBLED signaling pathways regulating cell growth pattern in Arabidopsis thaliana.
    5. TRY, but not the related factor CPC, is responsible for the preferential SCM accumulation.
      Title: TRIPTYCHON, not CAPRICE, participates in feedback regulation of SCM expression in the Arabidopsis root epidermis.
    6. importance of distinct kinase residues for these three developmental processes provides an explanation for the maintenance of the conserved kinase domain in the SCM protein
      Title: Distinct signaling mechanisms in multiple developmental pathways by the SCRAMBLED receptor of Arabidopsis.
    7. STRUBBELIG extracellular domain variant harbours considerable amounts of Glc1Man7GlcNAc2 N-glycans suggesting that the ER-quality control processes are tightly interconnected to promote protein folding or disposal.
      Title: A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation.
    8. The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana
      Title: The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana.
    9. QKY is localized at the plasma membrane and functions in a multiprotein complex that includes SUB and PAL OF QUIRKY, a previously uncharacterized PB1-domain-containing protein that localizes both at the plasma membrane and in intracellular compartments.
      Title: QUIRKY interacts with STRUBBELIG and PAL OF QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development.
    10. ANGUSTIFOLIA is a central component of tissue morphogenesis mediated by the atypical receptor-like kinase STRUBBELIG.
      Title: ANGUSTIFOLIA is a central component of tissue morphogenesis mediated by the atypical receptor-like kinase STRUBBELIG.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001331960.1
    NM_100986.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasmodesmata-mediated intercellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of atrichoblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of trichoblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_172580.2
    • STRUBBELIG (SUB); FUNCTIONS IN: receptor signaling protein serine/threonine kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat (InterPro:IPR001611), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: STRUBBELIG-receptor family 3 (TAIR:AT4G03390.1); Has 153928 Blast hits to 101875 proteins in 2737 species: Archae - 122; Bacteria - 10876; Metazoa - 38100; Fungi - 7570; Plants - 81122; Viruses - 718; Other Eukaryotes - 15420 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3722708..3727450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100986.4 → NP_172580.2  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172580.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04081, Q8RWZ1, Q9SXA2
      UniProtKB/TrEMBL
      A0A178WQB4, A0A5S9TUI2, C0LGE3
      Conserved Domains (3) summary
      PLN00113
      Location:83 → 765
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:95 → 116
      LRR_RI; leucine-rich repeat [structural motif]
      cl21453
      Location:503 → 765
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001331960.1 → NP_001321706.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARR6, A0A654E8X7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWZ1.1

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