SERAT2;1 serine acetyltransferase 2;1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: SERAT2;1
Official Full Name: serine acetyltransferase 2;1
Primary source: TAIR:AT1G55920
Locus tag: AT1G55920
See related: Araport:AT1G55920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSERAT2;1; F14J16.18; F14J16_18; SAT1; SAT5; SERINE ACETYLTRANSFERASE; SERINE ACETYLTRANSFERASE 1; serine acetyltransferase 2;1; SERINE ACETYLTRANSFERASE 5
Summary: Encodes a chloroplast/cytosol localized serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SERAT2;1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (20912116..20913565)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression in developing lupin embryos of a serine acetyltransferase (SAT) from Arabidopsis thaliana (AtSAT1 or AtSerat 2;1) was associated with increases of up to 5-fold in the concentrations of O-acetylserine and up to 26-fold in free cysteine.
Title: Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume.
Plastidic SERAT2;1 contributes less to OAS formation and subsequent Cys synthesis.
Title: Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
Cytosolic SERAT1.1 and plastidic SERAT2.1 do not contribute to cysteine biosynthesis.
Title: Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis.
Binding of the C-terminus of serine acetyltransferase by acetylserine sulfhydrylase contributes a large portion of the total binding energy during formation of the plant cysteine synthase complex.
Title: Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.
From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
Title: In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_104470.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine O-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine O-acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to sulfate starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: serine acetyltransferase 2;1

NP_175988.1

serine acetyltransferase 2;1 (SERAT2;1); FUNCTIONS IN: serine O-acetyltransferase activity; INVOLVED IN: cellular response to sulfate starvation, response to cold; LOCATED IN: cytosol, chloroplast, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexapeptide transferase, conserved site (InterPro:IPR018357), Serine O-acetyltransferase (InterPro:IPR005881), Trimeric LpxA-like (InterPro:IPR011004), Serine acetyltransferase, N-terminal (InterPro:IPR010493); BEST Arabidopsis thaliana protein match is: serine acetyltransferase 2;2 (TAIR:AT3G13110.1); Has 24449 Blast hits to 24415 proteins in 2638 species: Archae - 407; Bacteria - 18561; Metazoa - 8; Fungi - 223; Plants - 250; Viruses - 18; Other Eukaryotes - 4982 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

20912116..20913565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104470.3 → NP_175988.1 serine acetyltransferase 2;1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175988.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WT70, Q42588, Q43297

UniProtKB/TrEMBL

A0A178WQK2

Conserved Domains (1) summary

PLN02357
Location:1 → 314

PLN02357; serine acetyltransferase