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    MDAR6 monodehydroascorbate reductase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842697, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDAR6
    Official Full Name
    monodehydroascorbate reductase 6
    Primary source
    TAIR:AT1G63940
    Locus tag
    AT1G63940
    See related
    Araport:AT1G63940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    monodehydroascorbate reductase 6
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    Genomic context

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    See MDAR6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (23729875..23733974)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Copper transport protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monodehydroascorbate reductase mediates TNT toxicity in plants. Johnston EJ, et al. Science, 2015 Sep 4. PMID 26339024
    2. Molecular definition of the ascorbate-glutathione cycle in Arabidopsis mitochondria reveals dual targeting of antioxidant defenses in plants. Chew O, et al. J Biol Chem, 2003 Nov 21. PMID 12954611
    3. The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show differential sensitivity to short- and long-term exposure to low temperature. Goulas E, et al. Plant J, 2006 Sep. PMID 16923014
    4. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    5. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis deficient in MDHAR6 displays enhanced 2,4,6-trinitrotoluene tolerance.
      Title: Monodehydroascorbate reductase mediates TNT toxicity in plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105067.4
    NM_179508.3
    NM_179509.1
    NM_179510.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monodehydroascorbate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monodehydroascorbate reductase 6
    NP_564818.1
    • monodehydroascorbate reductase 6 (MDAR6); FUNCTIONS IN: ATP binding; INVOLVED IN: response to cadmium ion, response to cold; LOCATED IN: mitochondrion, stromule, chloroplast stroma, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 32682 Blast hits to 32615 proteins in 3080 species: Archae - 745; Bacteria - 25586; Metazoa - 997; Fungi - 665; Plants - 640; Viruses - 0; Other Eukaryotes - 4049 (source: NCBI BLink).
    NP_849839.1
    • monodehydroascorbate reductase 6 (MDAR6); FUNCTIONS IN: ATP binding; INVOLVED IN: response to cadmium ion, response to cold; LOCATED IN: mitochondrion, stromule, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 32816 Blast hits to 32747 proteins in 3098 species: Archae - 747; Bacteria - 25716; Metazoa - 998; Fungi - 665; Plants - 641; Viruses - 0; Other Eukaryotes - 4049 (source: NCBI BLink).
    NP_849840.1
    • monodehydroascorbate reductase 6 (MDAR6); FUNCTIONS IN: ATP binding; INVOLVED IN: response to cadmium ion, response to cold; LOCATED IN: mitochondrion, stromule, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 32449 Blast hits to 32388 proteins in 3070 species: Archae - 747; Bacteria - 25377; Metazoa - 989; Fungi - 665; Plants - 634; Viruses - 0; Other Eukaryotes - 4037 (source: NCBI BLink).
    NP_849841.1
    • monodehydroascorbate reductase 6 (MDAR6); FUNCTIONS IN: ATP binding; INVOLVED IN: response to cadmium ion, response to cold; LOCATED IN: mitochondrion, stromule, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 32339 Blast hits to 32274 proteins in 3053 species: Archae - 745; Bacteria - 25255; Metazoa - 989; Fungi - 665; Plants - 640; Viruses - 0; Other Eukaryotes - 4045 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23729875..23733974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179508.3 → NP_849839.1  monodehydroascorbate reductase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92947, Q94CE2, Q9CAK5
      UniProtKB/TrEMBL
      A0A178WFH3, A0A5S9WPJ2
      Conserved Domains (1) summary
      pfam07992
      Location:83 → 376
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_105067.4 → NP_564818.1  monodehydroascorbate reductase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHD0, A0A384KW24, A0A5S9WPJ2, B9DGR6
      Conserved Domains (1) summary
      pfam07992
      Location:76 → 369
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. NM_179509.1 → NP_849840.1  monodehydroascorbate reductase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WPJ2, F4I577
      Conserved Domains (2) summary
      pfam00070
      Location:211 → 293
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:76 → 369
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. NM_179510.1 → NP_849841.1  monodehydroascorbate reductase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WPJ2, F4I576
      Conserved Domains (2) summary
      pfam00070
      Location:211 → 293
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:76 → 369
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92947.3

    Gene LinkOut

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