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    ATTPS6 UDP-Glycosyltransferase / trehalose-phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843130, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATTPS6
    Official Full Name
    UDP-Glycosyltransferase / trehalose-phosphatase family protein
    Primary source
    TAIR:AT1G68020
    Locus tag
    AT1G68020
    See related
    Araport:AT1G68020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T23K23.13; T23K23_13; TPS6; TREHALOSE -6-PHOSPHATASE SYNTHASE S6
    Summary
    Encodes an enzyme putatively involved in trehalose biosynthesis. The protein has a trehalose synthase (TPS)-like domain and a trehalose phosphatase (TPP)-like domain. It can complement a yeast mutant lacking both of these activities suggesting that this is a bifunctional enzyme.
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    Genomic context

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    See ATTPS6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (25496928..25500584)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol synthase 1 Neighboring gene hydroxypyruvate reductase Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene flavin-binding, kelch repeat, f box 1 Neighboring gene microtubule-associated proteins 70-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trehalose-6-phosphate synthase/phosphatase regulates cell shape and plant architecture in Arabidopsis. Chary SN, et al. Plant Physiol, 2008 Jan. PMID 17981987, Free PMC Article
    2. Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Ramon M, et al. Plant Cell Environ, 2009 Aug. PMID 19344332
    3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that class II AtTPS6 regulates plant architecture, shape of epidermal pavement cells, and branching of trichomes.
      Title: Trehalose-6-phosphate synthase/phosphatase regulates cell shape and plant architecture in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334340.1
    NM_105472.3
    NM_202376.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables trehalose-phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables trehalose-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within trehalose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    UDP-Glycosyltransferase / trehalose-phosphatase family protein
    NP_564918.1
    • ATTPS6; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: trehalose phosphatase/synthase 5 (TAIR:AT4G17770.1); Has 3258 Blast hits to 3213 proteins in 972 species: Archae - 43; Bacteria - 1733; Metazoa - 120; Fungi - 641; Plants - 336; Viruses - 0; Other Eukaryotes - 385 (source: NCBI BLink).
    NP_974105.1
    • ATTPS6; CONTAINS InterPro DOMAIN/s: HAD-superfamily hydrolase, subfamily IIB (InterPro:IPR006379), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: trehalose phosphatase/synthase 5 (TAIR:AT4G17770.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25496928..25500584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202376.3 → NP_974105.1  UDP-Glycosyltransferase / trehalose-phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AH8, Q9C9W6
      UniProtKB/TrEMBL
      A0A178W5P7, A0A5S9WSW0, A0A654ENN8
      Conserved Domains (1) summary
      PLN02205
      Location:1 → 860
      PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]

    2. NM_001334340.1 → NP_001322467.1  UDP-Glycosyltransferase / trehalose-phosphatase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AH8, Q9C9W6
      UniProtKB/TrEMBL
      A0A178W5P7, A0A5S9WSW0, A0A654ENN8
      Conserved Domains (1) summary
      PLN02205
      Location:1 → 860
      PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]

    3. NM_105472.3 → NP_564918.1  UDP-Glycosyltransferase / trehalose-phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W8Q789
      Conserved Domains (3) summary
      cd03788
      Location:54 → 556
      GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
      pfam00982
      Location:54 → 557
      Glyco_transf_20; Glycosyltransferase family 20
      cl21460
      Location:606 → 674
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AH8.2

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