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    WIT2 WPP domain-interacting protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843224, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WIT2
    Official Full Name
    WPP domain-interacting protein 2
    Primary source
    TAIR:AT1G68910
    Locus tag
    AT1G68910
    See related
    Araport:AT1G68910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T6L1.9; T6L1_9; WPP domain-interacting protein 2
    Summary
    Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
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    Genomic context

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    See WIT2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (25908046..25911277, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Defensin-like (DEFL) family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin XI-i links the nuclear membrane to the cytoskeleton to control nuclear movement and shape in Arabidopsis. Tamura K, et al. Curr Biol, 2013 Sep 23. PMID 23973298
    2. Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Zhao Q, et al. Plant Cell, 2008 Jun. PMID 18591351, Free PMC Article
    3. Myosin-driven transport network in plants. Kurth EG, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28096376, Free PMC Article
    4. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Zhou X, et al. Nucleus, 2015. PMID 25759303, Free PMC Article
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The nuclear envelope localization of SUN1, SUN2, WIP1, and a truncated WIT2 does not depend on CRWN1.
      Title: Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084328.2
    NM_001198424.2
    NM_105565.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin XI tail binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of establishment or maintenance of cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WPP domain-interacting protein 2
    NP_001077797.1
    • WPP domain-interacting protein 2 (WIT2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 1 (TAIR:AT5G11390.1); Has 78273 Blast hits to 43073 proteins in 2436 species: Archae - 1217; Bacteria - 11946; Metazoa - 37438; Fungi - 6381; Plants - 3987; Viruses - 327; Other Eukaryotes - 16977 (source: NCBI BLink).
    NP_001185353.1
    • WPP domain-interacting protein 2 (WIT2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 1 (TAIR:AT5G11390.1).
    NP_177057.2
    • WPP domain-interacting protein 2 (WIT2); BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 1 (TAIR:AT5G11390.1); Has 80562 Blast hits to 45263 proteins in 2523 species: Archae - 1211; Bacteria - 12854; Metazoa - 37741; Fungi - 6730; Plants - 4174; Viruses - 347; Other Eukaryotes - 17505 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25908046..25911277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198424.2 → NP_001185353.1  WPP domain-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WI98
      Conserved Domains (1) summary
      TIGR02168
      Location:252 → 502
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_105565.3 → NP_177057.2  WPP domain-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177057.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQR0, Q9CAB0
      UniProtKB/TrEMBL
      A0A178WGL0
      Conserved Domains (1) summary
      TIGR02168
      Location:252 → 502
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001084328.2 → NP_001077797.1  WPP domain-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WI98
      Conserved Domains (1) summary
      TIGR02168
      Location:252 → 502
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MQR0.1

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