HCC1 electron transport SCO1/SenC family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: HCC1
Official Full Name: electron transport SCO1/SenC family protein
Primary source: TAIR:AT3G08950
Locus tag: AT3G08950
See related: Araport:AT3G08950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: homologue of the copper chaperone SCO1
Summary: Encodes HCC1, homologue of the copper chaperone SCO1 (synthesis of cytochrome c oxidase 1) from the yeast Saccharomyces cerevisiae. SCO1 encodes a mitochondrial protein that is essential for the correct assembly of complex IV in the respiratory chain. HCC1 is localized in the mitochondrion. A chimeric yeast Sco1-Arabidopsis HCC1 protein complements yeast Sco1 activity. Embryos of hcc1 mutants became arrested at various developmental stages, mostly at the heart stage.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for CuA assembly in Cytochrome c Oxidase.
Title: Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for Cu(A) assembly in Cytochrome c Oxidase.
HCC1 is the protein involved in COX biogenesis and that HCC2, that lacks the cysteines and histidine putatively involved in copper binding, functions in copper sensing and redox homeostasis.[HCC1]
Title: Plants contain two SCO proteins that are differentially involved in cytochrome c oxidase function and copper and redox homeostasis.
HCC1 is essential for embryo development in Arabidopsis.
Title: HCC1, the Arabidopsis homologue of the yeast mitochondrial copper chaperone SCO1, is essential for embryonic development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_111729.3

Function	Evidence Code	Pubs
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial cytochrome c oxidase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory chain complex IV assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

NP_566339.1

electron transport SCO1/SenC family protein; FUNCTIONS IN: copper ion binding; INVOLVED IN: copper ion transport, respiratory chain complex IV assembly, cellular copper ion homeostasis, cell redox homeostasis; LOCATED IN: mitochondrion, mitochondrial inner membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Synthesis of cytochrome c oxidase, Sco1/Sco2 (InterPro:IPR017276), Copper chaperone SCO1/SenC (InterPro:IPR003782), Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT4G39740.1); Has 4072 Blast hits to 4072 proteins in 1098 species: Archae - 11; Bacteria - 2439; Metazoa - 165; Fungi - 147; Plants - 84; Viruses - 0; Other Eukaryotes - 1226 (source: NCBI BLink).

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