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    DOX1 Peroxidase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DOX1
    Official Full Name
    Peroxidase superfamily protein
    Primary source
    TAIR:AT3G01420
    Locus tag
    AT3G01420
    See related
    Araport:AT3G01420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alpha-dioxygenase 1; ALPHA-DOX1; DIOX1; PADOX-1; plant alpha dioxygenase 1; T13O15.6; T13O15_6
    Summary
    Encodes an alpha-dioxygenase involved in protection against oxidative stress and cell death. Induced in response to Salicylic acid and oxidative stress. Independent of NPR1 in induction by salicylic acid.
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    Genomic context

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    See DOX1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (159450..162905, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tubulin-tyrosine ligase Neighboring gene ncRNA Neighboring gene NHL domain protein Neighboring gene uncharacterized protein Neighboring gene PsbQ-like 1 Neighboring gene ARM repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of α-Dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily. Goulah CC, et al. Biochemistry, 2013 Feb 26. PMID 23373518, Free PMC Article
    2. Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function. Liu W, et al. Plant Physiol Biochem, 2006 May-Jun. PMID 16889973
    3. Involvement of the Arabidopsis alpha-DOX1 fatty acid dioxygenase in protection against oxidative stress and cell death. De León IP, et al. Plant J, 2002 Jan. PMID 12060227
    4. alpha-oxidation of fatty acids in higher plants. Identification of a pathogen-inducible oxygenase (piox) as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid. Hamberg M, et al. J Biol Chem, 1999 Aug 27. PMID 10455113
    5. Leaf oil body functions as a subcellular factory for the production of a phytoalexin in Arabidopsis. Shimada TL, et al. Plant Physiol, 2014 Jan. PMID 24214535, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Determined is the X-ray crystal structure of Arabidopsis thaliana alpha-dioxygenase to 1.5 A resolution.
      Title: The crystal structure of α-Dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily.
    2. role of 9-lipoxygenases and alpha-dioxygenases in plants' defense
      Title: Role of 9-lipoxygenase and α-dioxygenase oxylipin pathways as modulators of local and systemic defense.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111008.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within (R)-2-hydroxy-alpha-linolenic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitric oxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to salicylic acid stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid alpha-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid alpha-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in monolayer-surrounded lipid storage body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peroxidase superfamily protein
    NP_186791.1
    • DOX1; FUNCTIONS IN: lipoxygenase activity; INVOLVED IN: in 6 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Haem peroxidase, animal (InterPro:IPR002007); BEST Arabidopsis thaliana protein match is: alpha dioxygenase (TAIR:AT1G73680.1); Has 1465 Blast hits to 1381 proteins in 214 species: Archae - 0; Bacteria - 94; Metazoa - 1085; Fungi - 168; Plants - 70; Viruses - 1; Other Eukaryotes - 47 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      159450..162905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111008.3 → NP_186791.1  Peroxidase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186791.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SGH6
      UniProtKB/TrEMBL
      A0A178V8W6, A0A5S9X860
      Conserved Domains (2) summary
      PLN02283
      Location:6 → 639
      PLN02283; alpha-dioxygenase
      pfam03098
      Location:90 → 608
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SGH6.1

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