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    mtLPD2 lipoamide dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mtLPD2
    Official Full Name
    lipoamide dehydrogenase 2
    Primary source
    TAIR:AT3G17240
    Locus tag
    AT3G17240
    See related
    Araport:AT3G17240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    lipoamide dehydrogenase 2; LIPOAMIDE DEHYDROGENASE 2
    Summary
    lipoamide dehydrogenase precursor
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    Genomic context

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    See mtLPD2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (5889663..5892332, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial LIPOAMIDE DEHYDROGENASE2, a key enzyme in oxidative metabolism. Chen W, et al. Plant Cell Environ, 2014 Mar. PMID 23961884
    2. Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. Lutziger I, et al. Plant Physiol, 2001 Oct. PMID 11598235, Free PMC Article
    3. Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. Timm S, et al. Plant Cell, 2015 Jul. PMID 26116608, Free PMC Article
    4. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    5. Proteomic approach to identify novel mitochondrial proteins in Arabidopsis. Kruft V, et al. Plant Physiol, 2001 Dec. PMID 11743114, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of mtLPD improves photosynthesis and, in turn, biomass accumulation in Arabidopsis. [mtLPD2]
      Title: Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana.
    2. These results indicate that mitochondrial lipoamide dehydrogenase is an important protein for determining the sensitivity of oxidative metabolism to arsenate in Arabidopsis.
      Title: The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial LIPOAMIDE DEHYDROGENASE2, a key enzyme in oxidative metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112601.3
    NM_112602.2
    NM_180674.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables cobalt ion binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables dihydrolipoyl dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding HDA PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoamide dehydrogenase 2
    NP_566570.3
    • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Mercuric reductase (InterPro:IPR000815); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 42827 Blast hits to 42792 proteins in 3281 species: Archae - 1167; Bacteria - 31429; Metazoa - 914; Fungi - 500; Plants - 625; Viruses - 0; Other Eukaryotes - 8192 (source: NCBI BLink).
    NP_566571.1
    • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 17511 Blast hits to 17511 proteins in 2716 species: Archae - 356; Bacteria - 12773; Metazoa - 655; Fungi - 312; Plants - 149; Viruses - 0; Other Eukaryotes - 3266 (source: NCBI BLink).
    NP_851005.1
    • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Mercuric reductase (InterPro:IPR000815); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 42670 Blast hits to 42637 proteins in 3263 species: Archae - 1164; Bacteria - 31277; Metazoa - 912; Fungi - 500; Plants - 625; Viruses - 0; Other Eukaryotes - 8192 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5889663..5892332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180674.4 → NP_851005.1  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851005.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBH6, Q9M5K2, Q9ZRQ0
      UniProtKB/TrEMBL
      A0A5S9WML4, A0A5S9XEH6, A0A654F9D0
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_112601.3 → NP_566570.3  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566570.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBH6, Q9M5K2, Q9ZRQ0
      UniProtKB/TrEMBL
      A0A5S9WML4, A0A5S9XEH6, A0A654F9D0
      Conserved Domains (1) summary
      cl39093
      Location:41 → 507
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. NM_112602.2 → NP_566571.1  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M5K2
      Conserved Domains (1) summary
      PRK06467
      Location:41 → 95
      PRK06467; dihydrolipoamide dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M5K2.1

    Gene LinkOut

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