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    GRX4 glutaredoxin 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820809, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRX4
    Official Full Name
    glutaredoxin 4
    Primary source
    TAIR:AT3G15660
    Locus tag
    AT3G15660
    See related
    Araport:AT3G15660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA GLUTAREDOXIN 4; ATGRX4; glutaredoxin 4
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    Genomic context

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    See GRX4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (5307694..5309624, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant/protein Neighboring gene uncharacterized protein Neighboring gene Rubredoxin-like superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Late embryogenesis abundant protein (LEA) family protein Neighboring gene Ran BP2/NZF zinc finger-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The function of glutaredoxin GRXS15 is required for lipoyl-dependent dehydrogenases in mitochondria. Moseler A, et al. Plant Physiol, 2021 Jul 6. PMID 33856472, Free PMC Article
    2. AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stress. Cheng NH. FEBS Lett, 2008 Mar 19. PMID 18275854
    3. The mitochondrial monothiol glutaredoxin S15 is essential for iron-sulfur protein maturation in Arabidopsis thaliana. Moseler A, et al. Proc Natl Acad Sci U S A, 2015 Nov 3. PMID 26483494, Free PMC Article
    4. Molecular definition of the ascorbate-glutathione cycle in Arabidopsis mitochondria reveals dual targeting of antioxidant defenses in plants. Chew O, et al. J Biol Chem, 2003 Nov 21. PMID 12954611
    5. Monothiol glutaredoxin-BolA interactions: redox control of Arabidopsis thaliana BolA2 and SufE1. Couturier J, et al. Mol Plant, 2014 Jan. PMID 24203231

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtGRX4 may have important functions in plant growth and development under extreme environments.
      Title: AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035627.3
    NM_112436.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables disulfide oxidoreductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein lipoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    glutaredoxin 4
    NP_001030704.1
    • glutaredoxin 4 (GRX4); FUNCTIONS IN: metal ion binding; INVOLVED IN: cell redox homeostasis; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutaredoxin (InterPro:IPR002109), Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutaredoxin-related protein (InterPro:IPR004480); BEST Arabidopsis thaliana protein match is: thioredoxin family protein (TAIR:AT4G04950.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566522.1
    • glutaredoxin 4 (GRX4); FUNCTIONS IN: metal ion binding; INVOLVED IN: cell redox homeostasis; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutaredoxin (InterPro:IPR002109), Glutaredoxin-related protein (InterPro:IPR004480), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin family protein (TAIR:AT4G04950.1); Has 5304 Blast hits to 5116 proteins in 1283 species: Archae - 26; Bacteria - 2189; Metazoa - 461; Fungi - 314; Plants - 385; Viruses - 0; Other Eukaryotes - 1929 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5307694..5309624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035627.3 → NP_001030704.1  glutaredoxin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGX1, Q8LBK6, Q9LW13
      UniProtKB/TrEMBL
      A0A178VHP8, A0A5S9XCM1, A0A7G2EL76
      Conserved Domains (1) summary
      cd03028
      Location:69 → 158
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    2. NM_112436.3 → NP_566522.1  glutaredoxin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGX1, Q8LBK6, Q9LW13
      UniProtKB/TrEMBL
      A0A178VHP8, A0A5S9XCM1, A0A7G2EL76
      Conserved Domains (1) summary
      cd03028
      Location:69 → 158
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LBK6.2

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